When It Comes to Older Adults, Language Matters: Journal of the American Geriatrics Society Adopts Modified American Medical Association Style - American Geriatric Society

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Smucker Foods of Canada Corp. Announces a Voluntary Recall on Select Golden Temple®, Swad®, and Maya® Flour Products in the U.S. Due to Possible E. Coli 0121 Contamination - FDA Safety Alerts & Drug Recalls

In collaboration with the U.S. Food and Drug Administration (FDA), Smucker Foods of Canada Corp. today announced a voluntary recall on specific production codes of Golden Temple®, Swad®, and Maya® flour products in the U.S. due to possible E. coli O121 contamination.

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FDA approves first generic Strattera for the treatment of ADHD - FDA Press Releases

The U.S. Food and Drug Administration today approved the first generic versions of Strattera (atomoxetine) to treat attention-deficit/hyperactivity disorder (ADHD) in pediatric and adult patients.

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Kroger Issues Allergy Alert on Undeclared Milk in Kroger Yellow Sponge Cake Dessert Cups - FDA Safety Alerts & Drug Recalls

The Kroger Co. has recalled Kroger Dessert Cups –Yellow Sponge Cake (6.5 oz., 6 Pack) sold in its retail stores because it contains undeclared milk. People who have an allergy or severe sensitivity to milk run the risk of a serious or life-threatening allergic reaction if they consume these products.

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Kroger Recalls Simple Truth Dry Roasted Macadamia Nuts Because of Possible Health Risk - FDA Safety Alerts & Drug Recalls

The Kroger Co. (NYSE: KR) today announced the recall of its Simple Truth Dry Roasted Macadamia Nuts due to potential Listeria monocytogenes contamination. A supplier reported the product may have the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems.

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Hemoglobin Concentration Influences N-Terminal Pro B-Type Natriuretic Peptide Levels in Hospitalized Older Adults with and without Heart Failure - American Geriatric Society

Objectives

To investigate the relationship between hemoglobin and N-terminal pro B-type natriuretic peptide (NT-proBNP) concentration in hospitalized older adults with or without a diagnosis of heart failure (HF).

Design

Cross-sectional study based on retrospective hospital records review.

Setting

Geriatric acute care ward.

Participants

Individuals aged 65 and older (N = 226; mean age 81.1), with (n = 104) and without (n = 122) a diagnosis of HF.

Measurements

Information was collected on demographic characteristics, comorbidities, and laboratory and echocardiographic data. The relationship between hemoglobin and NT-proBNP was evaluated using linear regression models adjusted for potential confounders.

Results

A negative association was found between NT-proBNP and hemoglobin (β = −0.226, P < .001). The regression coefficient was −0.114 (P = .04) in the subsample with HF and −0.191 (P < .001) in the subsample without HF. After adjustment for potential confounders, the inverse association between hemoglobin and NT-proBNP was confirmed in the whole sample (β = −0.182, P < .001), in those with HF (β = −0.136, P = .007), and in those without HF (β = −0.165, P = .003).

Conclusion

Hemoglobin concentration should be taken into account in the interpretation of NT-proBNP in hospitalized older adults, especially those without HF.

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Lupin Pharmaceuticals Inc. Announces a Nationwide Recall of Mibelas™ 24 Fe (Norethindrone Acetate and EthinylEstradiol 1mg/0.02mg Chewable Tablets and Ferrous Fumarate 75 mg) Tablets Due to Out of Sequence Tablets and Missing Expiry/Lot Information - FDA Safety Alerts & Drug Recalls

Baltimore, Maryland, Lupin Pharmaceuticals Inc. announced today that it has voluntarily recalled lot L600518, Exp 05/18 of Mibelas 24 Fe (Norethindrone Acetate and Ethinyl Estradiol 1 mg/0.02 mg chewable and ferrous fumarate 75 mg) Tablets at the consumer level. A confirmed market compliant indicated a packaging error, where the blister was rotated 180 degrees within the wallet, reversing the weekly tablet orientation and making the lot number and expiration date no longer visible. The first four days of therapy would have had four non-hormonal placebo tablets as opposed to the active tablets.

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Beyond the Individual: The Interdependence of Advance Directive Completion by Older Married Adults - American Geriatric Society

Objectives

To determine how individual and spousal demographic and health factors are associated with advance directive (AD) completion by married older adults.

Design

Dyadic structural equation modeling using the Actor-Partner Interdependence Model.

Setting

The 2004 to 2012 waves of the Health and Retirement Study.

Participants

Community-dwelling heterosexual married couples aged 65 and older (N = 2,243).

Measurements

Structural equation modeling with a probit link function was used to estimate associations between men's and women's age, education, health status, prior hospitalization or outpatient surgery in the past 10 years, regular health care provider, and household net assets and their own and their spouses’ probabilities of having an AD.

Results

Individual and spousal ages were each positively associated with AD completion for men and women. Those with higher education were more likely to possess ADs. Women's probabilities of having ADs were also positively associated with husbands’ education. Men whose wives’ were in poor health were less likely to have ADs. Men who were hospitalized or underwent outpatient surgery were more likely to have ADs, as were their wives. Women who had regular sources of health care were more likely to have completed ADs.

Conclusion

AD completion by older married adults is associated with both individual and spousal factors. How spouses influence one another's advance care planning differs by gender. Future research should account for the dyadic nature of advance care planning, as should public education efforts and interventions promoting AD completion.

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Seeking Value in Healthcare: The Importance of Generalists as Primary Care Physicians - American Geriatric Society

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Trienylfuranol A and trienylfuranone A–B: metabolites isolated from an endophytic fungus, Hypoxylon submoniticulosum, in the raspberry Rubus idaeus - Journal of Antibiotics

Trienylfuranol A and trienylfuranone A–B: metabolites isolated from an endophytic fungus, Hypoxylon submoniticulosum, in the raspberry Rubus idaeus

The Journal of Antibiotics 70, 721 (June 2017). doi:10.1038/ja.2017.18

Authors: Kevin M N Burgess, Ashraf Ibrahim, Dan Sørensen & Mark W Sumarah

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OSMAC approach leads to new fusarielin metabolites from Fusarium tricinctum - Journal of Antibiotics

OSMAC approach leads to new fusarielin metabolites from Fusarium tricinctum

The Journal of Antibiotics 70, 726 (June 2017). doi:10.1038/ja.2017.21

Authors: Catalina F Pérez Hemphill, Parichat Sureechatchaiyan, Matthias U Kassack, Raha S Orfali, Wenhan Lin, Georgios Daletos & Peter Proksch

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Ghanamycins A and B, two novel γ-butyrolactones from marine-derived streptomyces ghanaensis TXC6-16 - Journal of Antibiotics

Ghanamycins A and B, two novel γ-butyrolactones from marine-derived streptomyces ghanaensis TXC6-16

The Journal of Antibiotics 70, 733 (June 2017). doi:10.1038/ja.2017.37

Authors: Jia-hui Xu, Kang-bo Gu, Dao-Jing Zhang, Yuan-Guang Li & Li Tian

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Bioactive secondary metabolites produced by an endophytic fungus Gaeumannomyces sp. JS0464 from a maritime halophyte Phragmites communis - Journal of Antibiotics

Bioactive secondary metabolites produced by an endophytic fungus Gaeumannomyces sp. JS0464 from a maritime halophyte Phragmites communis

The Journal of Antibiotics 70, 737 (June 2017). doi:10.1038/ja.2017.39

Authors: Changyeol Lee, Soonok Kim, Wei Li, Sunghee Bang, Hanna Lee, Hyun-Jung Lee, Eun-Young Noh, Jung-Eun Park, Woo Young Bang & Sang Hee Shim

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Two new polyketides from the ascomycete fungus Leptosphaeria sp. - Journal of Antibiotics

Two new polyketides from the ascomycete fungus Leptosphaeria sp.

The Journal of Antibiotics 70, 743 (June 2017). doi:10.1038/ja.2017.5

Authors: Jie Lin, Renlei Wang, Guohua Xu, Zhengfeng Ding, Xueshen Zhu, Erwei Li & Ling Liu

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Streptomyces euryhalinus sp. nov., a new actinomycete isolated from a mangrove forest - Journal of Antibiotics

Streptomyces euryhalinus sp. nov., a new actinomycete isolated from a mangrove forest

The Journal of Antibiotics 70, 747 (June 2017). doi:10.1038/ja.2017.3

Authors: Kaushik Biswas, Jayanta D Choudhury, Riddhi Mahansaria, Malay Saha & Joydeep Mukherjee

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In vitro antibacterial activity of MGDG-palmitoyl from Oscillatoria acuminata NTAPC05 against extended-spectrum β-lactamase producers - Journal of Antibiotics

In vitro antibacterial activity of MGDG-palmitoyl from Oscillatoria acuminata NTAPC05 against extended-spectrum β-lactamase producers

The Journal of Antibiotics 70, 754 (June 2017). doi:10.1038/ja.2017.40

Authors: Abdul Azees Parveez Ahamed, Mohammed Uddin Rasheed, Kalilurrahuman Peer Muhamed Noorani, Nazar Reehana, Subramanian Santhoshkumar, Yousuff Mohamed Mohamed Imran, Naiyf S Alharbi, Chinnathambi Arunachalam, Sulaiman Ali Alharbi, Mohammad Abdulkader Akbarsha & Nooruddin Thajuddin

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Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candidaalbicans biofilm formation and hyphal growth - Journal of Antibiotics

Penicillenols from a deep-sea fungus Aspergillus restrictus inhibit Candidaalbicans biofilm formation and hyphal growth

The Journal of Antibiotics 70, 763 (June 2017). doi:10.1038/ja.2017.45

Authors: Jie Wang, Qi-Feng Yao, Muhammad Amin, Xu-Hua Nong, Xiao-Yong Zhang & Shu-Hua Qi

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Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus - Journal of Antibiotics

Synergistic effects of vancomycin and β-lactams against vancomycin highly resistant Staphylococcus aureus

The Journal of Antibiotics 70, 771 (June 2017). doi:10.1038/ja.2017.7

Authors: Fumiaki Tabuchi, Yasuhiko Matsumoto, Masaki Ishii, Keita Tatsuno, Mitsuhiro Okazaki, Tomoaki Sato, Kyoji Moriya & Kazuhisa Sekimizu

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The efficacy of different anti-microbial metals at preventing the formation of, and eradicating bacterial biofilms of pathogenic indicator strains - Journal of Antibiotics

The efficacy of different anti-microbial metals at preventing the formation of, and eradicating bacterial biofilms of pathogenic indicator strains

The Journal of Antibiotics 70, 775 (June 2017). doi:10.1038/ja.2017.10

Authors: Natalie Gugala, Joe A Lemire & Raymond J Turner

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Formal synthesis of Thienamycin - Journal of Antibiotics

Formal synthesis of Thienamycin

The Journal of Antibiotics 70, 781 (June 2017). doi:10.1038/ja.2017.44

Authors: Michał Pieczykolan, Bartłomiej Furman & Marek Chmielewski

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Aspergone, a new chromanone derivative from fungus Aspergillus sp. SCSIO41002 derived of mangrove soil sample - Journal of Antibiotics

Aspergone, a new chromanone derivative from fungus Aspergillus sp. SCSIO41002 derived of mangrove soil sample

The Journal of Antibiotics 70, 788 (June 2017). doi:10.1038/ja.2016.169

Authors: Bin Yang, Huaming Tao, Xiao-Chu Qin, Zhen Wang, Junde Dong, Xiuping Lin, Xuefeng Zhou, Jian-Lin Li, Zheng-Chao Tu & Yonghong Liu

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Acremopeptin, a new peptaibol from Acremonium sp. PF1450 - Journal of Antibiotics

Acremopeptin, a new peptaibol from Acremonium sp. PF1450

The Journal of Antibiotics 70, 791 (June 2017). doi:10.1038/ja.2017.15

Authors: Masatomi Iijima, Masahide Amemiya, Ryuichi Sawa, Yumiko Kubota, Takao Kunisada, Isao Momose, Manabu Kawada & Masakatsu Shibasaki

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New diketopiperazine derivatives with cytotoxicity from Nocardiopsis sp. YIM M13066 - Journal of Antibiotics

New diketopiperazine derivatives with cytotoxicity from Nocardiopsis sp. YIM M13066

The Journal of Antibiotics 70, 795 (June 2017). doi:10.1038/ja.2017.46

Authors: Mingwei Sun, Xiaotong Chen, Wenjun Li, Chunhua Lu & Yuemao Shen

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Identification of tirandamycins as specific inhibitors of the futalosine pathway - Journal of Antibiotics

Identification of tirandamycins as specific inhibitors of the futalosine pathway

The Journal of Antibiotics 70, 798 (June 2017). doi:10.1038/ja.2017.22

Authors: Yasushi Ogasawara, Kensuke Kondo, Ayumi Ikeda, Rikako Harada & Tohru Dairi

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Molecular epigenetic approach activates silent gene cluster producing dimeric bis-spiro-azaphilones in Chaetomium globosum CBS148.51 - Journal of Antibiotics

Molecular epigenetic approach activates silent gene cluster producing dimeric bis-spiro-azaphilones in Chaetomium globosum CBS148.51

The Journal of Antibiotics 70, 801 (June 2017). doi:10.1038/ja.2017.4

Authors: Meng-Hua Wang, Tao Jiang, Gang Ding, Shu-Bin Niu, Xue-Wei Wang, Meng Yu, Yu-Cheng Gu, Qiu-Bo Zhang, Jia-Huan Chen, Hong-Mei Jia & Zhong-Mei Zou

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Conjugative ESBL plasmids differ in their potential to rescue susceptible bacteria via horizontal gene transfer in lethal antibiotic concentrations - Journal of Antibiotics

Conjugative ESBL plasmids differ in their potential to rescue susceptible bacteria via horizontal gene transfer in lethal antibiotic concentrations

The Journal of Antibiotics 70, 805 (June 2017). doi:10.1038/ja.2017.41

Authors: Sari Mattila, Pilvi Ruotsalainen, Ville Ojala, Timo Tuononen, Teppo Hiltunen & Matti Jalasvuori

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Biochemical characterization of CTX-M-166, a new CTX-M β-lactamase produced by a commensal Escherichia coli isolate - Journal of Antibiotics

Biochemical characterization of CTX-M-166, a new CTX-M β-lactamase produced by a commensal Escherichia coli isolate

The Journal of Antibiotics 70, 809 (June 2017). doi:10.1038/ja.2017.42

Authors: Vera Manageiro, Rafael Graça, Eugénia Ferreira, Lurdes Clemente, Richard Bonnet & Manuela Caniça

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Long-Term Oral Bisphosphonate Therapy and Fractures in Older Women: The Women's Health Initiative - American Geriatric Society

Objectives

To examine the association between long-term bisphosphonate use and fracture in older women at high risk of fracture.

Design

Retrospective cohort.

Setting

Women's Health Initiative.

Participants

Older women who reported at least 2 years of bisphosphonate use in 2008–09 (N = 5,120).

Measurements

Exposure data were from a current medications inventory. Outcomes (hip, clinical vertebral, wrist or forearm, any clinical fracture) were ascertained annually. Using multivariate Cox proportional hazards models, the association between duration of bisphosphonate use (3–5, 6–9, 10–13 years) and fracture was estimated, using 2 years as the referent group.

Results

On average participants were 80 years old and were followed for 3.7 ± 1.2 years. There were 127 hip, 159 wrist or forearm, 235 clinical vertebral, and 1,313 clinical fractures. In multivariate-adjusted analysis, 10 to 13 years of bisphosphonate use was associated with higher risk of any clinical fracture than 2 years of use (hazard ratio (HR) = 1.29, 95% confidence interval (CI) = 1.07–1.57). This association persisted in analyses limited to women with a prior fracture (HR = 1.30, 95% CI = 1.01–1.67) and women with no history of cancer (HR = 1.36, 95% CI = 1.10–1.68). The association of 10 to 13 years of use, compared with 2 years of use, was not statistically significant for hip (HR = 1.66, 95% CI = 0.81–3.40), clinical vertebral (HR = 1.65, 95% CI = 0.99–2.76), or wrist fracture (HR = 1.16, 95% CI = 0.67–2.00).

Conclusion

In older women at high risk of fracture, 10 to 13 years of bisphosphonate use was associated with higher risk of any clinical fracture than 2 years of use. These results add to concerns about the benefit of very long-term bisphosphonate use.

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Have We Learned How to Use Bisphosphonates Yet? - American Geriatric Society

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Research Priorities to Advance the Health and Health Care of Older Adults with Multiple Chronic Conditions - American Geriatric Society

Objectives

To prioritize research topics relevant to the care of the growing population of older adults with multiple chronic conditions (MCCs).

Design

Survey of experts in MCC practice, research, and policy. Topics were derived from white papers, funding announcements, or funded research projects relating to older adults with MCCs.

Setting

Survey conducted through the Health Care Systems Research Network (HCSRN) and Claude D. Pepper Older Americans Independence Centers (OAICs) Advancing Geriatrics Infrastructure and Network Growth Initiative, a joint endeavor of the HCSRN and OAICs.

Participants

Individuals affiliated with the HCSRN or OAICs and national MCC experts, including individuals affiliated with funding agencies having MCC-related grant portfolios.

Measurements

A “top box” methodology was used, counting the number of respondents selecting the top response on a 5-point Likert scale and dividing by the total number of responses to calculate a top box percentage for each of 37 topics.

Results

The highest-ranked research topics relevant to the health and healthcare of older adults with MCCs were health-related quality of life in older adults with MCCs; development of assessment tools (to assess, e.g., symptom burden, quality of life, function); interactions between medications, disease processes, and health outcomes; disability; implementation of novel (and scalable) models of care; association between clusters of chronic conditions and clinical, financial, and social outcomes; role of caregivers; symptom burden; shared decision-making to enhance care planning; and tools to improve clinical decision-making.

Conclusion

Study findings serve to inform the development of a comprehensive research agenda to address the challenges relating to the care of this “high-need, high-cost” population and the healthcare delivery systems responsible for serving it.

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High C-Reactive Protein Predicts Delirium Incidence, Duration, and Feature Severity After Major Noncardiac Surgery - American Geriatric Society

Objectives

To examine associations between the inflammatory marker C-reactive protein (CRP) measured preoperatively and on postoperative day 2 (POD2) and delirium incidence, duration, and feature severity.

Design

Prospective cohort study.

Setting

Two academic medical centers.

Participants

Adults aged 70 and older undergoing major noncardiac surgery (N = 560).

Measurements

Plasma CRP was measured using enzyme-linked immunosorbent assay. Delirium was assessed from Confusion Assessment Method (CAM) interviews and chart review. Delirium duration was measured according to number of hospital days with delirium. Delirium feature severity was defined as the sum of CAM-Severity (CAM-S) scores on all postoperative hospital days. Generalized linear models were used to examine independent associations between CRP (preoperatively and POD2 separately) and delirium incidence, duration, and feature severity; prolonged hospital length of stay (LOS, >5 days); and discharge disposition.

Results

Postoperative delirium occurred in 24% of participants, 12% had 2 or more delirium days, and the mean ± standard deviation sum CAM-S was 9.3 ± 11.4. After adjusting for age, sex, surgery type, anesthesia route, medical comorbidities, and postoperative infectious complications, participants with preoperative CRP of 3 mg/L or greater had a risk of delirium that was 1.5 times as great (95% confidence interval (CI) = 1.1–2.1) as that of those with CRP less than 3 mg/L, 0.4 more delirium days (P < .001), more-severe delirium (3.6 CAM-S points higher, P < .001), and a risk of prolonged LOS that was 1.4 times as great (95% CI = 1.1–1.8). Using POD2 CRP, participants in the highest quartile (≥235.73 mg/L) were 1.5 times as likely to develop delirium (95% CI = 1.0–2.4) as those in the lowest quartile (≤127.53 mg/L), had 0.2 more delirium days (P < .05), and had more severe delirium (4.5 CAM-S points higher, P < .001).

Conclusion

High preoperative and POD2 CRP were independently associated with delirium incidence, duration, and feature severity. CRP may be useful to identify individuals who are at risk of developing delirium.

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Bone Turnover with Venlafaxine Treatment in Older Adults with Depression - American Geriatric Society

Objectives

Epidemiologic data suggest older adults receiving serotonergic antidepressants may have accelerated bone loss. We examined bone turnover marker changes and patient-level variables associated with these changes in older adults receiving protocolized antidepressant treatment.

Design

Open-label, protocolized treatment study.

Setting

Medical centers in Pittsburgh, St Louis, and Toronto.

Participants

Older adults with major depression (N = 168).

Measurements

Serum levels of the bone resorption marker C-terminal cross-linking telopeptide of type 1 collagen (CTX) and the bone formation marker procollagen type 1 N propeptide (P1NP) were assayed before and after 12 weeks of treatment with venlafaxine. Whether CTX and P1NP changes were associated with depression remission and duration of depression and genetic polymorphisms in the serotonin transporter (5HTTLPR) and 1B receptor (HTR1B) were also examined.

Results

CTX increased and P1NP decreased during venlafaxine treatment, a profile consistent with accelerated bone loss. Two individual-level clinical variables were correlated with bone turnover; participants whose depression did not go into remission had higher CTX levels, and those with chronic depression had lower P1NP levels. HTR1B genotype predicted P1NP change, whereas 5HTTLPR genotype was unrelated to either biomarker.

Conclusion

Bone turnover markers change with antidepressant treatment in a pattern that suggests accelerated bone loss, although the clinical significance of these changes is unclear. These data are preliminary and argue for a larger, controlled study to confirm whether antidepressants are harmful to bone metabolism and whether certain individuals might be at increased risk.

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Oral Health and Dental Care in Older Asian Americans in Central Texas - American Geriatric Society

Objectives

To examine factors associated with dental health insurance, self-rated oral health, and use of preventive dental care services in older Asian Americans.

Design

Cross-sectional survey.

Setting

The Asian American Quality of Life Survey was conducted with 2,614 Asian Americans living in central Texas using questionnaires available in English and six Asian languages.

Participants

Asian American Quality of Life Survey participants aged 60 and older (N = 533; mean age = 69.4 ± 6.9).

Measurements

Participants were asked whether they had insurance that covered the cost of any dental visit, how they would rate their overall oral health status, and whether they had visited a dental clinic for a routine examination in the past 12 months. Information was also collected on sociodemographic and immigration-related variables.

Results

More than 61% of the sample had no dental health insurance, 45% reported that their oral health was fair or poor, and 44% had not used preventive dental care services. A series of logistic regression analyses identified factors posing a significant risk to oral health and dental care. For example, those with limited English proficiency were 3.5 times as likely to lack dental health insurance and 3.2 times as likely to rate their oral health as fair or poor. The odds of not using preventive dental care services were 6.4 times as great in those without dental health insurance.

Conclusion

The overall findings call attention to efforts to promote oral health and dental care in older Asian Americans.

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A Sudden Loss Of Vision - American Geriatric Society

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Astrazeneca Initiates Voluntary Nationwide Recall of One Lot of Brilinta 90 mg Professional Sample Bottles Due to Report of Another Medicine in One Bottle From That Lot - FDA Safety Alerts & Drug Recalls

AstraZeneca today announced that the Company is notifying physicians and consumers that it is voluntarily recalling one lot of professional (physician) sample bottles containing eight tablets of BRILINTA (ticagrelor) 90mg tablets as a precautionary measure. This voluntary recall follows a report that a professional sample bottle containing eight tablets of BRILINTA 90mg also contained another medicine called ZURAMPIC (lesinurad) 200 mg tablets which is also manufactured by AstraZeneca.

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Recall on Fewer Than 225 Ava's Brand Organic Cashews Roasted & Salted 8 oz. Tubs in NJ, NY, PA and CT - FDA Safety Alerts & Drug Recalls

Hampton Farms is voluntarily recalling Ava's brand Organic Cashews Roasted & Salted 8 oz. tubs distributed in New Jersey, New York, Pennsylvania and Connecticut. We have been notified by our cashew supplier that the cashews used have the potential to be contaminated with Listeria monocytogenes. No confirmed illnesses have been reported to public health authorities to date.

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Caverflo.com Issues Voluntary Nationwide Recall of Caverflo Natural Herbal Coffee due to the Presence of Undeclared Active Pharmaceutical Ingredients and Undeclared Milk - FDA Safety Alerts & Drug Recalls

Caverflo.com is voluntarily recalling all lots of Caverflo Natural Herbal Coffee, 25 grams to the consumer level. FDA laboratory analysis confirmed the presence of Sildenafil and Tadalafil which are the active ingredients in two FDA-approved prescription drugs used for the treatment of erectile dysfunction (ED). Caverflo.com has received a report of an individual death after use of the coffee. Caverflo Natural Herbal Coffee may also contain undeclared milk.

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California Sun Dry Foods Announces a Voluntary Recall of Mislabeled California Sun Dry Sun-Dried Tomato Pesto Due to Undeclared Almond and Milk Allergen - FDA Safety Alerts & Drug Recalls

California Sun Dry Foods today issued a voluntary recall of California Sun Dry Sun-Dried Tomato Pesto because of a potentially incorrect back label on some jars. This mislabeling incident resulted in undeclared allergens (Almonds and Milk). People who have an allergy or severe sensitivity to tree nuts and milk run the risk of serious or life-threatening allergic reaction if they consume this product.

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Hail Merry Issues Voluntary Recall Due to Labeling Error - FDA Safety Alerts & Drug Recalls

Hail Merry LLC, a plant-based snack food company, voluntarily recalls its Meyer Lemon Mini Miracle Tart Party Pack of 6 from the market due to a labeling error. The products contain cashews as listed on the "Ingredients" label, however the "Contains" allergen warning statement does not specifically identify "cashews."

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Recall of Food Produced at Airway Heights Corrections Center - FDA Safety Alerts & Drug Recalls

TUMWATER – Based on recent events involving the water supply in Airway Heights, Wash., and out of an abundance of caution, the Washington Department of Corrections has issued a voluntary recall of the food manufactured by the Airway Heights Corrections Center’s Correctional Industries’ food production facility.

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MusclMasster LLC Issues Voluntary Nationwide Recall of Al-Er-G Capsules Because it Contains the Banned Substance Ephedra - FDA Safety Alerts & Drug Recalls

MusclMasster, LLC of Wheat Ridge, CO is recalling all bottles of Al-Er-G Capsules because they contain the presence of Ephedra Herb, an FDA banned ingredient. Dietary supplements containing ephedrine alkaloids pose a risk of serious adverse events, including heart attack, stroke, and death, and that these risks are unreasonable in light of any benefits that may result from the use of these products under their labeled conditions of use.

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Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines

Nuclear translocation of HIF-1α induced by influenza A (H1N1) infection is critical to the production of proinflammatory cytokines

Emerging Microbes & Infections 6, e39 (May 2017). doi:10.1038/emi.2017.21

Authors: Xinkun Guo, Zhaoqin Zhu, Wanju Zhang, Xiaoxiao Meng, Yong Zhu, Peng Han, Xiaohui Zhou, Yunwen Hu & Ruilan Wang

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Novel highly divergent sapoviruses detected by metagenomics analysis in straw-colored fruit bats in Cameroon

Novel highly divergent sapoviruses detected by metagenomics analysis in straw-colored fruit bats in Cameroon

Emerging Microbes & Infections 6, e38 (May 2017). doi:10.1038/emi.2017.20

Authors: Claude Kwe Yinda, Nádia Conceição-Neto, Mark Zeller, Elisabeth Heylen, Piet Maes, Stephen Mbigha Ghogomu, Marc Van Ranst & Jelle Matthijnssens

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A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein

A novel neutralizing monoclonal antibody targeting the N-terminal domain of the MERS-CoV spike protein

Emerging Microbes & Infections 6, e37 (May 2017). doi:10.1038/emi.2017.18

Authors: Yingzhu Chen, Shuai Lu, Hao Jia, Yao Deng, Jianfang Zhou, Baoying Huang, Yueyang Yu, Jiaming Lan, Wenling Wang, Yongliang Lou, Kun Qin & Wenjie Tan

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A new model of self-resolving leptospirosis in mice infected with a strain of Leptospira interrogans serovar Autumnalis harboring LPS signaling only through TLR4

A new model of self-resolving leptospirosis in mice infected with a strain of Leptospira interrogans serovar Autumnalis harboring LPS signaling only through TLR4

Emerging Microbes & Infections 6, e36 (May 2017). doi:10.1038/emi.2017.16

Authors: Bili Xia, Le Sun, Xia Fan, Haihan Xiao, Yongzhang Zhu, Jinhong Qin, Chengsong Cai, Wei Zhao, Yung-Fu Chang, Yan Zhang, Xiaokui Guo & Ping He

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Aetiology of acute meningoencephalitis in Cambodian children, 2010–2013

Aetiology of acute meningoencephalitis in Cambodian children, 2010–2013

Emerging Microbes & Infections 6, e35 (May 2017). doi:10.1038/emi.2017.15

Authors: Paul F Horwood, Veasna Duong, Denis Laurent, Channa Mey, Heng Sothy, Ky Santy, Beat Richner, Seiha Heng, Sopheak Hem, Justine Cheval, Christopher Gorman, Philippe Dussart, Menno D de Jong, Alexandra Kerleguer, Bertrand Guillard, Bernadette Murgue, Marc Lecuit, Xavier de Lamballerie, Jeremy J Farrar, Arnaud Tarantola, Marc Eloit & Philippe Buchy

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L.A. Lucky Brand Basil Seed 2.1 oz Voluntary Recall Because of Possible Health Risk - FDA Safety Alerts & Drug Recalls

L.A. Lucky Import & Export Inc. announced it is voluntarily recalling L.A. Lucky Brand Basil Seeds 2.1 oz due to presence of Salmonella in the packet. Salmonella is an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems.

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FDA approves first cancer treatment for any solid tumor with a specific genetic feature - FDA Press Releases

The U.S. Food and Drug Administration today granted accelerated approval to a treatment for patients whose cancers have a specific genetic feature (biomarker). This is the first time the agency has approved a cancer treatment based on a common biomarker rather than the location in the body where the tumor originated

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FDA approves first drug to specifically treat giant cell arteritis - FDA Press Releases

The U.S. Food and Drug Administration today expanded the approved use of subcutaneous Actemra (tocilizumab) to treat adults with giant cell arteritis. This new indication provides the first FDA-approved therapy, specific to this type of vasculitis.

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Anorexia of Aging - Geriatrics

Older people often experience loss of appetite and/or decreased food intake that, unavoidably, impact energy metabolism and overall health status. The association of age-related nutritional deficits with several adverse outcomes has led to the recognition of a geriatric condition referred to as “anorexia of aging.” Anorexia is an independent predictor of morbidity and mortality both in the community and across clinical settings. Multidimensional interventions within personalized care plans currently represent the most effective option to ensure the provision of adequate amounts of food, limit weight loss, and prevent adverse health outcomes in older adults.

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Dynamic Technical Formulations, LLC. Issues a Voluntary Nationwide Recall of Tri-Ton Due to the Presence of Andarine and Ostarine - FDA Safety Alerts & Drug Recalls

Dynamic Technical Formulations LLC. is voluntarily recalling all lots of Tri-Ton. This product was sold in 90 count bottles as a dietary supplement and includes all lot number and expiration dates of the product. The US Food and Drug Administration (FDA) lab analysis of Tri-Ton was found to contain andarine and ostarine which are selective androgen receptor modulators (SARMs) that are considered unapproved drugs and anabolic steroid-like substances.

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Exercise or Social Intervention for Nursing Home Residents with Dementia: A Pilot Randomized, Controlled Trial - American Geriatric Society

Objectives

To compare the effects of exercise with those of a structured nonphysical intervention on ability to perform activities of daily living (ADLs) and physical and cognitive function of persons with dementia (PWDs) living in nursing homes (NH).

Design

Cluster-randomized pilot-controlled trial.

Setting

Seven French NHs.

Participants

PWDs living in NHs.

Measurements

NHs were randomized to an exercise group (4 NHs, n = 47) or structured social activity group (3 NHs, n = 50) for a 24-week intervention performed twice per week for 60 minutes per session. The main endpoint was ADL performance (Alzheimer's Disease Cooperative Study Activities of Daily Living Inventory for Severe Alzheimer's Disease Scale (ADCS-ADL-sev); range 0–54, higher is better); secondary endpoints were overall cognitive function (Mini-Mental State Examination (MMSE)) and performance-based tests of physical function (Short Physical Performance Battery (SPPB), usual gait speed).

Results

Ninety-one participants with at least one postbaseline ADL assessment were included in efficacy analysis. Groups differed at baseline in terms of sex, neuropsychiatric symptoms, and nutritional status. Multilevel analysis adjusted for baseline differences between groups found no significant difference between effects of exercise and social activity (group-by-time interaction), with adjusted mean differences at 6 months of 1.9 points for ADCS-ADL-sev and 0.55 points for MMSE favoring social activity and 0.6 points for SPPB and 0.05 m/s favoring exercise. Adverse events did not differ between groups, except that the social activity group had more falls than the exercise group.

Conclusion

A larger, longer trial is required to determine whether exercise has greater health benefits than nonphysical interventions for institutionalized PWDs.

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“Urinary Tract Infection”—Requiem for a Heavyweight - American Geriatric Society

“Urinary tract infection” (“UTI”) is an ambiguous, expansive, overused diagnosis that can lead to marked, harmful antibiotic overtreatment. “Significant bacteriuria,” central to most definitions of “UTI,” has little significance in identifying individuals who will benefit from treatment. “Urinary symptoms” are similarly uninformative. Neither criterion is well defined. Bacteriuria and symptoms remit and recur spontaneously. Treatment is standard for acute uncomplicated cystitis and common for asymptomatic bacteriuria, but definite benefits are few. Treatment for “UTI” in older adults with delirium and bacteriuria is widespread but no evidence supports the practice, and expert opinion opposes it.

Sensitive diagnostic tests now demonstrate that healthy urinary tracts host a ubiquitous, complex microbial community. Recognition of this microbiome, largely undetectable using standard agar-based cultures, offers a new perspective on “UTI.” Everyone is bacteriuric (and viruric). From this perspective, most people who are treated for a “UTI” would probably be better off without treatment. Elderly adults, little studied in this regard, face particular risk. Invasive bacterial diseases such as pyelonephritis and bacteremic bacteriuria are also “UTIs.”

Mindful decisions about antibiotic use will require a far better understanding of how pathogenicity arises within microbial communities. It is likely that public education and meaningful informed-consent discussions about antibiotic treatment of bacteriuria, emphasizing potential harms and uncertain benefits, would reduce overtreatment. Emphasizing the microbiome's significance and using the term “urinary tract dysbiosis” instead of “UTI” might also help and might encourage mindful study of the relationships among host, aging, microbiome, disease, and antibiotic treatment.

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Effect of Spironolactone on Exercise Tolerance and Arterial Function in Older Adults with Heart Failure with Preserved Ejection Fraction - American Geriatric Society

Objectives

To evaluate the effects of an aldosterone antagonist on exercise intolerance in older adults with heart failure and preserved ejection fraction (HFpEF).

Design

Randomized, placebo-controlled, double-blind trial.

Setting

Academic medical center, Winston-Salem, North Carolina.

Participants

Older adults (N = 80, aged 71 ± 1; 80% female) with stable compensated HFpEF and controlled blood pressure (BP).

Measurements

Participants were randomized into a 9-month treatment of spironolactone 25 mg/d vs placebo. Assessments were peak exercise oxygen consumption (VO₂), 6-minute walk test, Minnesota Living with Heart Failure Questionnaire (MLHFQ), cardiac magnetic resonance imaging, Doppler echocardiography, and vascular ultrasound.

Results

Seventy-one participants completed the trial: 37 in the spironolactone group and 34 in the placebo group. Adherence according to pill count was excellent (spironolactone 95%, placebo 97%). Mean spironolactone dose was 24.3 ± 2.9 mg/d and was well tolerated. Spironolactone significantly reduced systolic and diastolic BP at rest and peak exercise. At 9-month follow-up, baseline-adjusted peak VO_2, the primary outcome, was 13.5 ± 0.3 mL/kg per minute in the spironolactone group versus 13.9 ± 0.3 mL/kg per minute in the placebo group (adjusted mean difference −0.4 mL/kg per minute; 95% confidence interval = −1.1–0.4 mL/kg per minute; P = .38). The 95% confidence intervals of spironolactone's effect on peak VO₂ (−8.2% to 3.2%) excluded a clinically significant beneficial effect. There were also no significant differences in 6-minute walk distance, arterial stiffness, left ventricular (LV) mass, LV mass/end-diastolic volume, or MLHFQ score.

Conclusion

In older adults with stable compensated HFpEF, 9 months of spironolactone 25 mg/d was well tolerated and reduced BP but did not improve exercise capacity, quality of life, LV mass, or arterial stiffness.

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Old and Alone - American Geriatric Society

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Rapid Geriatric Assessment of Hip Fracture - Geriatrics

A comprehensive geriatric assessment, combined with a battery of imaging and blood tests, should be able to identify those hip fracture patients who are at higher risk of short- and long-term complications. This comprehensive assessment should be followed by the implementation of a comprehensive multidimensional care plan aimed to prevent negative outcomes in the postoperative period (short and long term), thus assuring a safe and prompt functional recovery while also preventing future falls and fractures.

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Brightfarms Announces Voluntary Regional Recall of Produce Due to Potential Presence of Metal Pieces From Construction - FDA Safety Alerts & Drug Recalls

BrightFarms is initiating a voluntary recall of packaged produce sold in Giant Food stores due to the potential presence of metal as a result of construction at its Elkwood, Virginia (Culpeper County) greenhouse farm.

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Wang GlobalNet Issues Allergy Alert Undeclared Eggs, Wheat In “Fish Cake, Fish Ball, And Fish Tofu” - FDA Safety Alerts & Drug Recalls

Wang Globalnet of Moonachie, NJ is recalling 5 Cases of Fish Cake (Item#:13125), 2 cases of Fish Ball (Item#: 20072), 186 Cases of Fish Cake (Item#: 12842), 4 Cases of Fish Cake (Item#: 15731), and 3 Cases of Fish Tofu (Item#: 17185) because it may contain undeclared egg and wheat. People who have an allergy or severe sensitivity to eggs and wheat run the risk of serious or life-threatening allergic reaction if they consume these products.

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La Nica Products, Inc. Retira Queso Por Posible Riesgo De Salud - FDA Safety Alerts & Drug Recalls

La Nica Products, Inc. de Miami, FL está retirando seis mil libras de queso, ya que puede estar contaminada con Listeria monocytogenes, un organismo que puede causar infecciones graves y a veces fatales en niños pequeños, personas débiles o ancianas y otros con sistemas inmunológicos debilitados. Las personas sanas pueden sufrir síntomas de corto plazo como fiebre alta, dolor de cabeza intenso, rigidez, náuseas, dolor abdominal y diarrea, infección por listeria puede causar abortos espontáneos y mortinatos entre las mujeres embarazadas.

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Mild Cognitive Impairment - Geriatrics

Mild cognitive impairment (MCI) occurs along a continuum from normal cognition to dementia. A roadblock to earlier diagnosis and potential treatment is the lack of consistency with screening for MCI. Universal screening would be ideal, but is limited. Once a diagnosis of MCI is made, it is important for the clinician to evaluate for reversible causes. At present time, there are no pharmacologic treatments proven to slow or cure progression of MCI to dementia; nonetheless, there is evidence that lifestyle modifications including diet, exercise, and cognitive stimulation may be effective.

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Henning’s Cheese voluntarily recalls Colby Jack cheese - FDA Safety Alerts & Drug Recalls

Henning’s Cheese located in Kiel, Wisconsin, announced today that it is voluntarily recalling a limited amount of its Colby Jack cheese due to a temporary pasteurizer malfunction. Due to the malfunction, verification of proper pasteurization is not possible. No illnesses have been reported related to consumption of this product and no other Henning’s Cheese products are affected by this recall.

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FDA expands approved use of Kalydeco to treat additional mutations of cystic fibrosis - FDA Press Releases

The U.S. Food and Drug Administration today expanded the approved use of Kalydeco (ivacaftor) for treating cystic fibrosis. The approval triples the number of rare gene mutations that the drug can now treat, expanding the indication from the treatment of 10 mutations, to 33. The agency based its decision, in part, on the results of laboratory testing, which it used in conjunction with evidence from earlier human clinical trials. The approach provides a pathway for adding additional, rare mutations of the disease, based on laboratory data.

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Global Garlic Inc. Recalls Queso Fresco/ Whole Milk Cheese Because Of Possible Health Risk - FDA Safety Alerts & Drug Recalls

Global Garlic Inc. of Miami, Florida is recalling 227 units of Queso Fresco/ Whole Milk Cheese, because it has the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems. Although healthy individuals may suffer only short-term symptoms such as high fever, severe headache, stiffness, nausea, abdominal pain and diarrhea, listeria infection can cause miscarriages and stillbirths among pregnant women.

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Expanding the Field of Surgical Researchers: The Jahnigen Career Development Award - American Geriatric Society

Under a long-standing collaboration with the John A. Hartford Foundation (JAHF), the Atlantic Philanthropies (AP), and specialty societies in 10 targeted specialties, the American Geriatrics Society (AGS) has been working to improve quality of care provided to older adults by surgical and related medical specialists. To support and nurture future academic leaders, the Geriatrics-for-Specialists Initiative (GSI) established the Dennis W. Jahnigen Career Development Scholar Award (JCDA) program in 2002, with AP joining JAHF as a core funder of the awards in 2003. Commencing in 2011, the National Institute on Aging (NIA) launched the Grants for Early Medical/Surgical Specialists’ Transition to Aging Research (GEMSSTAR) program, using an RO3 mechanism. Recipients of the JCDA and the GEMSSTAR are provided with 2 years of research support and networking opportunities with other scholars; 79 JCDA and 26 surgical and related medical specialty GEMSSTAR scholars have been funded through these award mechanisms, with AGS, JAHF, and surgical and related medical specialty societies providing matching support for 20 of the GEMSSTAR scholars for leadership development programs. One of the primary criteria for judging the overall success of the program was eventual transition of the award to a federally funded program, which was achieved when NIA launched the GEMSSTAR program in 2011.

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Improving Specialty Care of Older Adults: Creating Champions, Supporting Research, Fostering Partnerships - American Geriatric Society

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Meeting the Need for Training in Geriatrics: The Geriatrics Education for Specialty Residents Program - American Geriatric Society

The imperative created by increasing numbers of aging Americans coupled with increasing longevity has generated recognition and acceptance within american medicine that education, from medical school through postgraduate training through continuing medical education, must include appropriate knowledge and skills in aging and geriatrics to provide for effective care of older adults. Such education and training is necessary not only for traditional primary care providers, but also for specialty physicians, including those in most surgical specialties and in related fields such as anesthesiology, emergency medicine and physical medicine and rehabilitation. To fill this demand, the American Geriatrics Society Geriatrics for Specialist Initiative established the Geriatrics Education for Specialty Residents Program (GSR). This article reviews the process by which the GSR created a dynamic cohort of geriatric surgical educators and researchers who in turn created a vibrant body of educational tools and scientific works that continue to advance the cause of improving medical care of older adults.

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Geriatrics-for-Specialists Initiative: An Eleven-Specialty Collaboration to Improve Care of Older Adults - American Geriatric Society

In the early 1990s, visionary leaders at the American Geriatrics Society and The John A. Hartford Foundation recognized that the marked and growing shortage of geriatrics healthcare professionals would lead to a U.S. healthcare system ill prepared to provide optimal care for the ever-increasing number of older Americans. Led by the late Dennis W. Jahnigen, MD, they set forth a plan to address this shortage by collaborating with surgical and related medical specialists to create a series of programs to foster the highest quality care of older adults. Their unique programmatic vision was that every physician, not just geriatricians, would have basic knowledge and skills in geriatric care, because geriatricians cannot and should not meet the need alone.

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FDA warns Americans about risk of inaccurate results from certain lead tests - FDA Press Releases

The U.S. Food and Drug Administration and Centers for Disease Control and Prevention are warning Americans that certain lead tests manufactured by Magellan Diagnostics may provide inaccurate results for some children and adults in the United States.

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La Nica Products, Inc. Recalls Cheese Because of Possible Health Risk - FDA Safety Alerts & Drug Recalls

La Nica Products, Inc. of Miami, FL is recalling six thousand pounds of cheese, because it has the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems. Although healthy individuals may suffer only short-term symptoms such as high fever, severe headache, stiffness, nausea, abdominal pain and diarrhea, listeria infection can cause miscarriages and stillbirths among pregnant women.

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Italian Gluten Free Food Cl Issues Allergy Alert On Undeclared Egg In “Chef Luca’s Lasagna Al Forno – Baked Cheese Lasagna” - FDA Safety Alerts & Drug Recalls

Italian Gluten Free Food CL of 1899 Bushwick Avenue, Merrick, NY 11566, is recalling its 15 ounce packages of “Chef Luca’s LASAGNA AL FORNO BAKED CHEESE LASAGNA” food because they may contain undeclared egg. People who have allergies to eggs run the risk of serious or life- threatening allergic reaction if they consume these products.

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Abbott Initiates Voluntarily Recall of Specific Lots of Three Coronary Catheters - FDA Safety Alerts & Drug Recalls

Abbott has initiated a voluntary recall of specific lots of three catheters: NC Trek RX Coronary Dilatation Catheter, NC Traveler Coronary Dilatation Catheter, and NC Tenku RX PTCA Balloon Catheter.

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Green Chile Concepts, Llc Voluntarily Recalls Select Product Codes And Production Dates Of Green Chile Food Company Brand Burrito Products - FDA Safety Alerts & Drug Recalls

Green Chile Concepts, LLC is voluntarily recalling certain Green Chile Food Company brand burritos sold frozen, refrigerated and/or served hot in certain convenience stores, vending machines, and retail locations nationwide because they may have the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems. Although healthy individuals may suffer only short- term symptoms such as high fever, severe headache, stiffness, nausea, abdominal pain and diarrhea, Listeria infection can cause miscarriages and stillbirths among pregnant women.

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The Horton Fruit Company, Inc. Issues Voluntary Recall of Fresh Spinach Because of Possible Health Risk - FDA Safety Alerts & Drug Recalls

The Horton Fruit Co., Inc. (“Horton”) of Louisville, KY is voluntarily recalling select bags and containers of fresh spinach because it has the potential to be contaminated with Listeria monocytogenes. The company was alerted to the potential of contamination by their supplier partners, and conducting a subsequent internal investigation.

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Allergy Alert Issued by Arabella Station Whole Foods Market for Undeclared Walnuts in Oatmeal Chocolate Chip Cookies - FDA Safety Alerts & Drug Recalls

The Arabella Station Whole Foods Market store, located at 5600 Magazine Street in New Orleans, is voluntarily recalling packaged oatmeal chocolate chip cookies because the product contained tree nut allergens (walnuts) that were not listed on the product label. People who have an allergy or severe sensitivity to walnuts run the risk of serious or life-threatening allergic reaction if they consume these products.

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Rapid Geriatric Assessment - Geriatrics

The Rapid Geriatric Assessment (RGA) measures frailty, sarcopenia, anorexia, cognition, and advanced directives. The RGA is a screen for primary care physicians to be able to detect geriatric syndromes. Early intervention when geriatric syndromes are recognized can decrease disability, hospitalization, and mortality.

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Dissecting Delirium - Geriatrics

Delirium is an acute change in attention and awareness that preferentially occurs in older patients with acute illness. This review provides an overview for clinicians with descriptions of the presentations (phenotypes), consequences, diagnosis, and screening of delirium. In addition, this review provides guidance for the challenges posed by delirium in a health care system, including implementation of delirium programs, tools to address the diagnosis and differential diagnosis of delirium, and a review of preventive and treatment studies with a goal of improving clinical practice.

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Cognitive Frailty - Geriatrics

Physical frailty is often associated with cognitive impairment, possibly because of common underlying pathophysiologic mechanisms. To stimulate research in this field, the concept cognitive frailty was proposed, emphasizing the important role of brain aging. Cognitive frailty was defined as the presence of cognitive deficits in physically frail older persons without dementia. This subtype of frailty is deemed important, as it may represent a prodromal phase for neurodegenerative diseases and is potentially a suitable target for early intervention. The aim of this report is to refine the framework for the definition and mechanisms of cognitive frailty and relevant screening tools.

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Sarcopenia - Geriatrics

Sarcopenia refers to age-related muscle loss, defined using a combination of appendicular muscle mass, muscle strength, and physical performance measures. The pathogenesis depends on a balance between positive and negative regulators of muscle growth. Sarcopenia increases the risk for falls, fractures, dependency, use of hospital services, institutionalization, poor quality of life, and mortality. In clinical practice, brief screening tools, such as the 5-item SARC-F score, may be useful. Although pharmacologic treatments are actively being studied, the current mainstay consists of optimizing nutrition status, in particular protein and vitamin D status, and resistance exercises.

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FDA authorizes use of new device to treat esophageal birth defect in babies - FDA Press Releases

The U.S. Food and Drug Administration today authorized use of the Flourish Pediatric Esophageal Atresia Anastomosis, a first-of-its-kind medical device to treat infants up to one year old for a birth defect that causes a gap in their esophagus, called esophageal atresia.

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Lamb Weston Issues Allergy Alert on Undeclared Milk in Red Robin Burgers and Brews Crispy Onion Rings Sold in Grocery Stores - FDA Safety Alerts & Drug Recalls

Lamb Weston is recalling 14 ounce packages of Red Robin Burgers and Brews Crispy Onion Rings manufactured by Fry Foods and sold in grocery stores, because the product may contain an undeclared milk allergen. People who have an allergy or severe sensitivity to milk run the risk of serious or life-threatening allergic reaction if they consume this product.

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Trident Seafoods Corporation Recalls Frozen Multi-Grain Alaskan Cod Due to Possible Health Risk - FDA Safety Alerts & Drug Recalls

Trident Seafoods Corporation is issuing a voluntary recall of select lots of frozen Multi-Grain Alaskan Cod, Net Wt. 12, oz., because they may contain small pieces of plastic. Consumption of these products may pose a choking hazard or other physical injury to the mouth.

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Time for a New Approach to Studying Older People with Ischemic Heart Disease - American Geriatric Society

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Mikawaya Issues Allergy Alert On Undeclared Peanuts In Limited Quantity Of Mikawaya Chocolate Chocolate Mochi Ice Cream - FDA Safety Alerts & Drug Recalls

Mikawaya is issuing a voluntary recall of a limited number of Mikawaya Brand Chocolate Chocolate Mochi Ice Cream, which may inadvertently contain peanuts. People who have an allergy or severe sensitivity to peanuts run the risk of a serious or life-threatening allergic reaction if they consume the product. Only product labeled with UPC code of 070934990609 and lot number LOT 090-17 is included in this recall. The UPC code can be found on the back of the box and the lot number is printed on the top enclosure.

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Wegmans Food Markets Issues Allergy Alert On Undeclared Egg In Wegmans Family Pack Food You Feel Good About Net. Weight 48 ozs. (3 LB.) 1.36 KG Potato Salad - FDA Safety Alerts & Drug Recalls

A.S.K. Foods, Inc. of Palmyra, Pennsylvania is voluntarily recalling one lot of Wegmans Family Pack Food You Feel Good About Net Wt. 48 oz. (3 LB.) 1.46 KG Potato Salad because it may contain undeclared egg. People who have an allergy or severe sensitivity to egg run the risk of serious or life-threatening allergic reaction if they consume these products.

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Global and local environmental changes as drivers of Buruli ulcer emergence

Global and local environmental changes as drivers of Buruli ulcer emergence

Emerging Microbes & Infections 6, e34 (May 2017). doi:10.1038/emi.2017.45

Authors: Marine Combe, Camilla Jensen Velvin, Aaron Morris, Andres Garchitorena, Kevin Carolan, Daniel Sanhueza, Benjamin Roche, Pierre Couppié, Jean-François Guégan & Rodolphe Elie Gozlan

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Humoral cross-reactivity between Zika and dengue viruses: implications for protection and pathology

Humoral cross-reactivity between Zika and dengue viruses: implications for protection and pathology

Emerging Microbes & Infections 6, e33 (May 2017). doi:10.1038/emi.2017.42

Authors: Lalita Priyamvada, William Hudson, Rafi Ahmed & Jens Wrammert

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Humoral cross-reactivity between Zika and dengue viruses: implications for protection and pathology

Humoral cross-reactivity between Zika and dengue viruses: implications for protection and pathology

Emerging Microbes & Infections 6, e33 (May 2017). doi:10.1038/emi.2017.42

Authors: Lalita Priyamvada, William Hudson, Rafi Ahmed & Jens Wrammert

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Seroepidemiology of enterovirus D68 infection in China

Seroepidemiology of enterovirus D68 infection in China

Emerging Microbes & Infections 6, e32 (May 2017). doi:10.1038/emi.2017.14

Authors: Zichun Xiang, Linlin Li, Lili Ren, Li Guo, Zhengde Xie, Chunyan Liu, Taisheng Li, Ming Luo, Gláucia Paranhos-Baccalà, Wenbo Xu & Jianwei Wang

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Crowdsourcing-based nationwide tick collection reveals the distribution of Ixodes ricinus and I. persulcatus and associated pathogens in Finland

Crowdsourcing-based nationwide tick collection reveals the distribution of Ixodes ricinus and I. persulcatus and associated pathogens in Finland

Emerging Microbes & Infections 6, e31 (May 2017). doi:10.1038/emi.2017.17

Authors: Maija Laaksonen, Eeva Sajanti, Jani J Sormunen, Ritva Penttinen, Jari Hänninen, Kai Ruohomäki, Ilari Sääksjärvi, Eero J Vesterinen, Ilppo Vuorinen, Jukka Hytönen & Tero Klemola

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Full genetic characterization and epidemiology of a novel amdoparvovirus in striped skunk (Mephitis mephitis)

Full genetic characterization and epidemiology of a novel amdoparvovirus in striped skunk (Mephitis mephitis)

Emerging Microbes & Infections 6, e30 (May 2017). doi:10.1038/emi.2017.13

Authors: Marta Canuti, Hillary E Doyle, Ann P Britton & Andrew S Lang

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Emergence of IntI1 associated blaVIM-2 gene cassette-mediated carbapenem resistance in opportunistic pathogen Pseudomonas stutzeri

Emergence of IntI1 associated blaVIM-2 gene cassette-mediated carbapenem resistance in opportunistic pathogen Pseudomonas stutzeri

Emerging Microbes & Infections 6, e29 (May 2017). doi:10.1038/emi.2017.12

Authors: Sabrin Bashar, Santonu Kumar Sanyal, Munawar Sultana & M Anwar Hossain

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Quality Nut Co. Issues a Voluntary Recall - FDA Safety Alerts & Drug Recalls

Quality Nut Co. of Massillon, Ohio is voluntarily recalling the following products due to undeclared allergens:

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Publix Recalls Private Label Brand of Deli Artichoke and Spinach Dip Due to Possible Health Risk - FDA Safety Alerts & Drug Recalls

Publix Super Markets is issuing a voluntary recall for Publix Deli Artichoke and Spinach Dip due to the possibility of the product containing small glass fragments. The 16 oz. artichoke and spinach dip was sold at Publix stores in Florida, Georgia, South Carolina, North Carolina , Alabama and Tennessee with a UPC of 000-41415-15961, and a use-by-date of May 16 A1 and May 16 C1,which is printed on the lid of the container. The product in question is found in the refrigerated cases in the deli.

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Fourth Street Barbecue/Packing Division Recalls Save-A-Lot Pick 5 Mix & Match Chicken & Waffle Sandwich Because Of Possible Health Risk - FDA Safety Alerts & Drug Recalls

Fourth Street Barbecue Inc. Packing Division has initiated a voluntary recall of all lot numbers of the Save-A-Lot Pick 5 Chicken Waffle Sandwich distributed nationwide as it has the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems. Although healthy individuals may suffer only short-term symptoms such as high fever, severe headache, stiffness, nausea, abdominal pain and diarrhea, Listeria infection can cause miscarriages and stillbirths among pregnant women.

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Physical Abuse of Elderly Adults: Victim Characteristics and Determinants of Revictimization - American Geriatric Society

Objectives

To describe victim characteristics and determinants of recurrent physical abuse of elderly.

Design

Multicenter retrospective analysis of multiple data systems to study victims of elder mistreatment in the greater Chicago metropolitan area.

Setting

Five teaching hospitals with Level 1 trauma centers.

Participants

Individuals aged 60 and older treated for physical and sexual abuse between 2000 and 2011.

Measurements

History of revictimization was based on hospital admission histories, Adult Protective Services records, and self-report. Death records were also linked to participant files.

Results

Fifty-eight individuals (52.3%) out of 111 cases suffering physical abuse had documented histories of revictimization. Based on multivariable models, individuals who were female, widowed, diagnosed with dementia, and returning to the home where the perpetrator lived or visited were substantially more likely to be revictimized. Revictimized individuals were more likely to be assaulted through unarmed force by a proximal relative, in particular a husband, boyfriend, child, or child-in-law. Based on hospital records, only 57% of community-dwelling cases had their abuse reported to Adult Protective Services or the police, and only 26.6% had Adult Protective Services investigations on record.

Conclusion

Better screening that connects victims of abuse with community services, police action, and alternative residential options is important in reducing the risk of revictimization and connecting individuals with resources that can improve their safety at home, regardless of whether it is in the community or a residential facility.

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Is Geriatric Medicine Possible in a Middle-Income Country? The Case of Costa Rica - American Geriatric Society

This article outlines the current and future-projected demographic data, organization, networks for the care of older people, and perspectives in Costa Rica in relation to the challenges resulting from exponential growth of the older adult population, most notably those aged 80 and older. It includes consideration of the Norms of Integrated Care of the Older Adult of Costa Rica's national social security system and contributions from other public and private institutions. It also makes note of commentaries on the need for ever-increasing efforts to manage the care of Costa Rica's burgeoning older adult population.

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A Moving Target—Medicare Beneficiaries Coming to the End of Long Lives - American Geriatric Society

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C.O. Truxton, Inc. Issues Voluntary Nationwide Recall of Amitriptyline HCL Tablets, USP 50mg and Phenobarbital Tablets, USP 15mg, 30mg, 60mg, 100mg Due to Potential Label Mix-Up - FDA Safety Alerts & Drug Recalls

Bellmawr, New Jersey, C.O. Truxton, Inc. is expanding their 04/21/2017 voluntary recall, as a precaution to include the following C.O. Truxton, Inc. products, registered NDC numbers and corresponding lot numbers, to the consumer/user level. C.O. Truxton has not received any complaints for the products listed below. however, due to the initial recall resulting from a label mix-up error, out of an abundance of caution, we are recalling all products that were repackaged into a Truxton Incorporated label.

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Spontaneously Reported Symptoms by Informants Are Associated with Clinical Severity in Dementia Help-Seekers - American Geriatric Society

Objectives

To investigate the predictive value of symptoms of dementia that the person or an informant noticed spontaneously in determining the clinical severity of dementia.

Design

Cross-sectional.

Setting

Community-based open-referral dementia assessment service in Hong Kong between 2005 and 2013.

Participants

Help-seekers for dementia assessment service and their informants (N = 965 dyads).

Measurements

Participants underwent a clinical dementia interview based on the Clinical Dementia Rating. Spontaneous complaints that the person and the informant made that had prompted their help-seeking of groups with interview results suggestive of no impairment, mild cognitive impairment, and dementia were compared. Logistic regression was used to evaluate the predictive value of spontaneous complaints for clinical severity. Independent raters blinded to clinical results coded spontaneously reported symptoms into theoretical themes: memory, executive function, language, time and place orientation, neuropsychiatric, mood, and avolition.

Results

Memory problems were the most frequently reported complaints for participants (87.7%) and their informants (95.5%), followed by self-reported language (33.0%) and informant-reported orientation (33.0%) difficulties. Informant-reported but not self-reported symptoms predicted clinical severity. Compared with the persons themselves, informants reported more pervasive symptoms corresponding to clinical severity. Persons with dementia self-reported fewer types of symptoms than their healthy or mildly impaired counterparts. Spontaneously reported language and orientation symptoms by the informant distinguished persons with mild or worse dementia (P < .001, Nagelkerke coefficient of determination = 29.7%, percentage correct 85.6%).

Conclusion

The type and pervasiveness of symptoms spontaneously that informants reported predicted clinical severity. This may provide a quick reference for triage.

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The Physical and Cognitive Performance Test for Residents in Assisted Living Facilities - American Geriatric Society

Objectives

To develop and evaluate the psychometric properties of a new performance-based instrument (Physical and Cognitive Performance Test for Assisted Living Facilities (PCPT ALF)) designed to assess the physical and cognitive skills associated with performance of activities of daily living (ADLs) and instrumental activities of daily living (IADLs).

Design

There were three stages in this study: development of instrument items and validity testing, a feasibility pilot study, and a cross-sectional trial to establish construct and criterion validity and reliability.

Setting

One 116-bed assisted living facility (ALF).

Participants

After a pilot test with 10 residents, a cross-sectional trial was conducted with 55 additional residents.

Measurements

The Barthel Index and Functional Independence Measure were used to estimate criterion validity. Construct validity was examined using exploratory factor analyses (EFAs).

Results

Disattenuated correlations between the PCPT ALF and other tools were all greater than 0.72, supporting criterion validity. Internal consistency (physical ability, α = 0.95; cognitive support, α = 0.92) and 1-week test–retest reliability (PCPT ALF, P = .93) were high, as was interrater reliability (IRR) (physical ability, 0.99; cognitive support, 1.00). In two EFAs, a one-factor solution accounted for 64.1% of the variance for the physical ability subscale and 63.5% of the variance for the cognitive support subscale.

Conclusion

The findings provide early evidence of the PCPT ALF's validity and reliability. If confirmed, this study's findings may be used in future work to assess the success of interventions to prevent or slow decline in the skills associated with ADL and IADL performance in ALFs.

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Comment on: How U.S. Doctors Die: A Cohort Study of Healthcare Use at the End of Life - American Geriatric Society

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Pioneers in Geriatrics – Passing It On - American Geriatric Society

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Reply to Comment on: How U.S. Doctors Die: A Cohort Study of Healthcare Use at the End of Life - American Geriatric Society

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Smallbatch Pets Inc. Voluntarily Recalls Frozen 2LB Chicken Blend For Dogs And Cats Due To Possible Salmonella Health Risk - FDA Safety Alerts & Drug Recalls

Smallbatch Pets Inc. of Portland, Oregon is voluntarily recalling two lots of frozen 2lbs. chicken blend for dogs and cats, brand name Smallbatch, due to the potential to be contaminated with Salmonella.

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FDA approves drug to treat ALS - FDA Press Releases

The U.S. Food and Drug Administration today approved Radicava (edaravone) to treat patients with amyotrophic lateral sclerosis (ALS), commonly referred to as Lou Gehrig’s disease.

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Genetic Edge Compounds Issues Voluntary Nationwide Recall of GEC Laxoplex Dietary Supplement Capsules Due to Presence of Anabolic Steroids - FDA Safety Alerts & Drug Recalls

Genetic Edge Compounds is voluntarily recalling all lot codes distributed between February 2, 2015- May 2, 2017 of GEC Laxoplex dietary supplement capsules, packaged in a white plastic bottle containing 60 capsules to the retail level and consumer level. Food and Drug Administration (“FDA”) analysis has found GEC Laxoplex to be tainted with anabolic steroids and steroid like substances.

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Pinnacle Foods Inc. Voluntarily Recalls Aunt Jemima Frozen Pancakes, Frozen Waffles & Frozen French Toast Slices Due to Possible Listeria Contamination - FDA Safety Alerts & Drug Recalls

Pinnacle Foods Inc. is voluntarily recalling all “Best By” dates of Aunt Jemima Frozen Pancakes, Frozen Waffles & Frozen French Toast Slices distributed nationally in the United States and one product into Mexico because they have the potential to be contaminated with Listeria monocytogenes. No illnesses have been reported. The products are being recalled as a precautionary measure given the health and safety of our consumers is our top priority. Pinnacle Foods initiated the recall after testing indicated the presence of Listeria monocytogenes in the plant environment.

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FDA takes action against Florida medicated animal feed manufacturer - FDA Press Releases

On May 4, 2017, the United States District Court for the Southern District of Florida entered a consent decree of permanent injunction between the United States and Syfrett Feed Company Inc. of Okeechobee, Florida; its owner and President Charles B. Syfrett I; Vice President Melissa S. Montes De Oca; and Operations Manager Charles B. Syfrett II. The consent decree requires the company to adequately control its production of medicated animal feeds and to comply with federal law before it can resume its medicated feed operations.

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Herbalife International Of America, Inc. Issues Voluntary Recall For Its Protein Bar – Peanut Butter Due To Trace Amounts Of Undeclared Fish Allergen - FDA Safety Alerts & Drug Recalls

LOS ANGELES, CA – May 1, 2017 – Herbalife (NYSE:HLF), a premier global nutrition company, is voluntarily recalling certain lots of its Protein Bar – Peanut Butter because the product may contain a trace amount of fish gelatin, which was added to the product as part of a flavoring ingredient provided by a third-party supplier. The amount of gelatin in the finished product is extremely low (approximately 0.02%). The gelatin is a highly processed collagen from fish skin, which contains a negligible amount of parvalbumin, a fish allergen.

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Unilever Issues Allergy Alert on Undeclared Peanut in Limited Quantity of Ben & Jerry’s Chocolate Fudge Brownie Pint Slices - FDA Safety Alerts & Drug Recalls

Unilever is voluntarily recalling a limited number of boxes of Ben & Jerry’s Chocolate Fudge Brownie Pint Slices, which may inadvertently contain Vanilla Peanut Butter Cup Pint Slices. Although the slices were individually wrapped and identified as Vanilla Peanut Butter Cup Pint Slices, the ingredient peanut butter (containing the known allergen peanut), is undeclared on the outer product packaging.

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Alzheimer's Disease: Individuals, Dyads, Communities, and Costs - American Geriatric Society

Alzheimer's disease and related dementias (ADRD) affect over 5 million Americans. Over a typical disease course of 5–10 years, family caregivers provide the majority of the day-to-day hands-on on care for persons with dementia. Most caregivers enter this complex role with little training and inadequate household resources and they are tasked to navigate a fragmented health care system as well as a patchwork of community services. Our nation can and should do more to help family caregivers provide care in the home to their loved ones who suffer from dementia. We will all benefit if we design and implement a better system of care for persons with dementia. We will benefit financially as a nation, we will benefit morally as a community, and in case we have forgotten, we stand to benefit ourselves as we age and face our own aging brain. Building a system of care requires excellent science and engineering, but we also need creative approaches that design systems of care that are available nationwide because they are scalable and affordable. Most importantly, families need our help now. We need to move faster.

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Now Health Group Inc. Voluntarily Recalls Select Ellyndale® Nutty Infusions™ - FDA Safety Alerts & Drug Recalls

NOW Health Group, Inc. (NOW), of Bloomingdale, Illinois, is voluntarily recalling its Ellyndale® Nutty Infusions™ Roasted Cashew Butter – Product Code E0540, Lot# 2125155, and Ginger Wasabi Cashew Butter – Product Code E0541, Lot# 2124118 because they have the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems. Although healthy individuals may suffer only short-term symptoms such as high fever, severe headache, stiffness, nausea, abdominal pain and diarrhea, Listeria infection can cause miscarriages and stillbirths among pregnant women.

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U.S. Deer Antler EX. & IM., INC. Announces The Recall Of Herbal Tea Varieties In Pouches Due To Risk For Clostridium Botulinum - FDA Safety Alerts & Drug Recalls

U.S. Deer Antler Ex. & Imp., of Los Angeles, CA is recalling a variety of Herbal Teas prepared on premises between 4/1/17 and 4/30/17 in cooperation with an inspection made by the California Department of Public Health. The aforementioned Herbal Teas, especially those with low-acidity held at room temperature, were not produced according to approved guideline, making them susceptible to contamination by Clostridium botulinum.

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Physicians Report Sleep Apnea Infrequently in Older and Older Vulnerable Adults - American Geriatric Society

Objectives

To determine how often outpatient physician visits detect sleep apnea (SA) in older persons in the United States.

Design

Retrospective Analysis.

Setting

US non hospital and hospital based clinics.

Participants

US physicians.

Measurements

National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey data from 1993 to 2011 were used to assess the frequency of physicians' coding diagnoses of SA in persons aged 65 and older. Which specialties are most likely to report SA, the most-common comorbid conditions reported with SA, and the likelihood of reporting SA in patient visits for dementia and preoperative care were assessed.

Results

From 1993 to 2011, physicians reported SA in 0.3% of all office visits in persons aged 65 and older. SA reported in visits increased from 130,000 in 1993 to 2,070,000 in 2011, with an annual per capita visit reporting rate of 0.07% to 0.74%. In older populations, the proportion of documented SA visits by specialists rose, and that of primary care providers decreased. Older adults with a diagnosis of SA had higher average number of comorbidities than those without SA (1.8 vs 1.3). Reporting SA was low in visits with a diagnosis of dementia and classified as a preoperative visits.

Conclusion

In two nationwide surveys, SA reporting by physicians in elderly adults was 16 as greater in 2001 as in 1993, although reporting of SA remains infrequent (<1% of visits) even in vulnerable populations.

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Imported Frozen Raw Tuna (Ahi) Cubes Distributed on Oahu Test Positive for Hepatitis A; Voluntary Product Recall Underway - FDA Safety Alerts & Drug Recalls

The Hawaii State Department of Health (DOH) has been notified of imported frozen raw tuna or ahi cubes distributed by Tropic Fish Hawaii, LLC on Oahu that tested positive for hepatitis A. The product, imported from Indonesia, was used to prepare poke sold between April 27 – May 1 by food establishments on Oahu.

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ReFlow Medical Issues Recall of Specific Lots of Wingman35 Crossing Catheters - FDA Safety Alerts & Drug Recalls

On April 22, 2017, ReFlow Medical initiated a lot-specific voluntary recall of the Wingman35 Crossing Catheters.

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Function Begets Function and Resilience in Old Age: Is Precision Gerontology Possible? - American Geriatric Society

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Opioids and Other Central Nervous System–Active Polypharmacy in Older Adults in the United States - American Geriatric Society

Objectives

To determine patterns of and trends in contributions to central nervous system (CNS) polypharmacy, defined by the Beers Criteria as three or more CNS-active medications of each medication class, of adults aged 65 and older seen in U.S. outpatient medical practices.

Design

National Ambulatory Medical Care Survey (2004–2013).

Setting

U.S. outpatient medical care.

Participants

Visits by older adults to outpatient physicians (N = 97,910).

Measurements

Visits including three or more CNS medications including antipsychotics, benzodiazepines, nonbenzodiazepine benzodiazepine receptor agonist hypnotics (NBRAs), tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and opioids. The proportion of CNS polypharmacy that each medication class contributed during 2011 to 2013 was determined, and then logistic regression was used to determine trends from 2004 to 2013 in the contribution of individual medication classes to such polypharmacy.

Results

Of recent CNS polypharmacy visits, 76.2% included an opioid, and 61.8% included a benzodiazepine; 66.0% of the polypharmacy visits with benzodiazepines included opioids, and 53.3% of the polypharmacy visits with opioids included benzodiazepines. Between 2011 and 2013, opioid and benzodiazepine co-prescribing occurred at approximately 1.50 million visits (95% confidence interval (CI) = 1.23–1.78 million) annually. From 2004 (reference) to 2013, the proportion of polypharmacy visits with opioids rose from 69.6% to 76.2% (adjusted odds ratio = 2.15, 95% CI = 1.19–3.91, P = .01), and the corresponding proportion that included benzodiazepines fell. Of the polypharmacy visits, the odds of SSRI, NBRA, and antipsychotic use were unchanged, and that of TCAs decreased.

Conclusion

In older adults, opioid use appears to be largely driving the recent national increase in CNS polypharmacy. Although concomitant use of opioids and benzodiazepines is associated with greater mortality, they are the most common contributors to CNS polypharmacy in older adults.

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Latent Tuberculosis Infection Testing Practices in Long-Term Care Facilities, Boston, Massachusetts - American Geriatric Society

Objectives

To describe latent tuberculosis infection (LTBI) testing practices in long-term care facilities (LTCFs).

Design

Retrospective cohort study.

Setting

Three Boston-area LTCFs.

Participants

Residents admitted between January 1 and December 31, 2011.

Measurements

Resident demographic characteristics, comorbidities, LTCF stay, and LTBI testing and treatment.

Results

Data for 291 LTCF residents admitted in 2011 were reviewed. Of the 257 without a history of LTBI and with documentation of testing, 162 (63%) were tested; 114 of 186 (61%) with a stay less than 90 days and 48 of 71 (68%) with a stay of 90 days or longer were tested. Of 196 residents with data on prior LTBI testing, 39 (19.9%) had LTBI; 12 of these (30.8%) were diagnosed at the LTCF. Hispanic participants were more likely than black participants to undergo LTBI testing (adjusted odds ratio (aOR) = 2.4, P = .003). Having a length of stay of less than 90 days (aOR = 0.7, P < .001) and history of illicit drug use (aOR = 0.7, P < .001) were associated with lower odds of LTBI testing.

Conclusion

One-fifth of LTCF residents had LTBI, but testing was not always performed. The high prevalence of LTBI in older adults combined with the risk of an outbreak if a case of tuberculosis occurs in a LTCF make LTBI testing and treatment an important prevention opportunity. The importance of LTBI testing in LTCFs needs to be reinforced.

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