Forthcoming Issues - Geriatrics

Falls Prevention

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Contents - Geriatrics

Fred A. Luchette and Robert D. Barraco

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Contributors - Geriatrics

FRED A. LUCHETTE, MD, MSc

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Copyright - Geriatrics

ELSEVIER

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Surgery and the Geriatric Patient - Geriatrics

CLINICS IN GERIATRIC MEDICINE

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Nuances of Surgical Care for the Elderly - Geriatrics

Unprecedented population growth, complex medical problems, and widespread use of anticoagulants: the perfect storm for the Silver Tsunami. Those aged 65 and over will number 98.2 million in the United States in the year 2060, with 19.7 million aged 85 and over.1 Arthritis, heart disease, cancer, pulmonary disease, and Alzheimer round out the top five health concerns in the elderly per the Centers for Disease Control and Prevention. However, the unspoken epidemic is that of frailty, with 44% of the elderly prefrail and 10% frail.

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Surgical Oncology and Geriatric Patients - Geriatrics

Geriatric medicine is a growing field filled with complicated patients who are susceptible to developing cancer. Surgical oncology is expanding while adapting to the increasing elderly population and creating novel treatment regimens for this group of patients. This article reviews surgical oncology in elderly patients and addresses surgical optimization, management of several cancer subtypes, surgical advances in minimally invasive surgery, and ethical considerations.

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FDA authorizes first direct-to-consumer test for detecting genetic variants that may be associated with medication metabolism - FDA Press Releases

FDA authorizes first direct-to-consumer test for detecting genetic variants that may be associated with medication metabolism

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Statement from FDA Commissioner Scott Gottlieb, M.D., on meetings with industry related to the agency’s ongoing policy commitment to firmly address rising epidemic rates in youth e-cigarette use - FDA Press Releases

Statement from FDA Commissioner Scott Gottlieb, M.D., on meetings with industry related to the agency’s ongoing policy commitment to firmly address rising epidemic rates in youth e-cigarette use.

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Sciegen Pharmaceuticals, Inc. Issues Voluntary Nationwide Recall of Irbesartan Tablets, USP 75 Mg, 150 Mg, and 300 Mg Due to The Detection of Trace Amounts of NDEA (N-Nitrosodiethylamine) Impurity Found in The Active Pharmaceutical Ingredient (API) - FDA Safety Alerts & Drug Recalls

ScieGen Pharmaceuticals, Inc. is voluntarily recalling listed lots, within expiry, of Irbesartan Tablets, USP 75 mg, 150 mg, and 300 mg dosage forms to the consumer level. These products are being recalled due to the presence of an impurity, N-nitrosodiethylamine (NDEA) contained in the API Irbesartan, USP manufactured by Aurobindo Pharma Limited. This impurity, which is a substance that occurs naturally in certain foods, drinking water, air pollution, and industrial processes, has been classified as a probable human carcinogen as per International Agency for Research on Cancer (IARC)

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FDA takes action to stop the use of lead acetate in hair dyes - FDA Press Releases

FDA takes action to stop the use of lead acetate in hair dyes. FDA will no longer allow lead acetate to be used in certain hair coloring products based on data that demonstrate that there is no longer a reasonable certainty of no harm from the use of this color additive.

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Statement from FDA Commissioner Scott Gottlieb, M.D., and Deputy Commissioner Anna Abram on the FDA’s new plan to advance plant, animal biotechnology innovation - FDA Press Releases

FDA announces new plan to advance the development of plant and animal biotechnology innovation

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Food Recall of Fit & Active Southwest Veggie Stuffed Sandwiches Due to Possible Listeria monocytogenes and Salmonella Contamination in Vegetables - FDA Safety Alerts & Drug Recalls

J&J Snack Foods Handheld Corp. of Holly Ridge, NC is voluntarily recalling two lots of Fit & Active Southwest Veggie Stuffed Sandwiches due to potential contamination with Listeria monocytogenes and Salmonella. Salmonella is an organism that can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems.

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Aurobindo Pharma Limited Issues Voluntary Recall of Irbesartan Drug Substance due to the Detection of Trace Amounts of NDEA (NNitrosodiethylamine) Impurity Found in the Active Pharmaceutical Ingredient (API) - FDA Safety Alerts & Drug Recalls

Aurobindo Pharma Limited is voluntarily recalling 22 Batches of the drug substance Irbesartan due to the presence of an impurity, N-nitrosodiethylamine (NDEA). The impurity, which is a substance that occurs naturally in certain foods, drinking water, air pollution, and industrial processes, has been classified as a probable human carcinogen as per International Agency for Research on Cancer (IARC).

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Maribel’s Sweets Inc. Allergy Alert on Undeclared Milk Allergens in Chocolate Bars - FDA Safety Alerts & Drug Recalls

Maribel’s Sweets Inc. of Brooklyn, NY is recalling its 2.82oz MarieBelle Japanese Matcha Japanese Green Tea and White Chocolate Bar, container code 101619, Cacao Market by MarieBelle Rosemary Truffle Salt 60% Dark Chocolate Bar, all container codes, and the Cacao Market by MarieBelle Orange Peels 60% Dark Chocolate Bar, all container codes, because they may contain undeclared milk allergens. Consumers who are allergic to milk allergens may run the risk of serious or life-threatening allergic reactions if they consume this product.

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Statement from FDA Commissioner Scott Gottlieb, M.D., on the FDA’s new consideration of labeling for sesame allergies - FDA Press Releases

Food allergies have touched the lives of most of us. Thousands of Americans experience life-threatening, food-related reactions each year, and an estimated 20 people die from them annually. In some cases, such reactions occur despite a careful reading of packaged food labels by conscientious consumers. To me, that’s unacceptable. The FDA is committed to advancing our efforts to help ensure that Americans have access to the information they need about common allergens in packaged foods.

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Curvulaide A, a bicyclic polyketide with anti-anaerobic bacteria activity from marine-derived Curvularia sp. - Journal of Antibiotics

Curvulaide A, a bicyclic polyketide with anti-anaerobic bacteria activity from marine-derived Curvularia sp.

Curvulaide A, a bicyclic polyketide with anti-anaerobic bacteria activity from marine-derived <i>Curvularia</i> sp., Published online: 26 October 2018; doi:10.1038/s41429-018-0110-7

Curvulaide A, a bicyclic polyketide with anti-anaerobic bacteria activity from marine-derived Curvularia sp.

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Urgent: Curry Spice Recall - FDA Safety Alerts & Drug Recalls

This voluntary recall has been initiated by UBC Food Distributors Inc, due to a high level of lead found in the product after testing was done by the Michigan Department of Agriculture & Rural Development, which found high traces of lead.

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Augmented antibacterial activity of ampicillin with silver nanoparticles against methicillin-resistant Staphylococcus aureus (MRSA) - Journal of Antibiotics

Augmented antibacterial activity of ampicillin with silver nanoparticles against methicillin-resistant Staphylococcus aureus (MRSA)

Augmented antibacterial activity of ampicillin with silver nanoparticles against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA), Published online: 25 October 2018; doi:10.1038/s41429-018-0111-6

Augmented antibacterial activity of ampicillin with silver nanoparticles against methicillin-resistant Staphylococcus aureus (MRSA)

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Inhibition effect of flavophospholipol on conjugative transfer of the extended-spectrum β-lactamase and vanA genes - Journal of Antibiotics

Inhibition effect of flavophospholipol on conjugative transfer of the extended-spectrum β-lactamase and vanA genes

Inhibition effect of flavophospholipol on conjugative transfer of the extended-spectrum β-lactamase and <i>vanA</i> genes, Published online: 25 October 2018; doi:10.1038/s41429-018-0113-4

Inhibition effect of flavophospholipol on conjugative transfer of the extended-spectrum β-lactamase and vanA genes

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Shirley’s Cookie Company In. Issues Allergy Alert on Undeclared Peanuts in "Chocolate Whoopie Pie" - FDA Safety Alerts & Drug Recalls

Shirley’s Cookie Company Inc. of Claysburg, PA, is recalling its 16 ounce packages of "Chocolate Whoopie Pie" because they may contain undeclared peanuts. People who have allergies to peanuts run the risk of serious or life-threatening allergic reaction if they consume these products.

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FDA permits marketing of a diagnostic test to aid in the determination of menopausal status - FDA Press Releases

FDA permits marketing of a diagnostic test to aid in the determination of menopausal status

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Statement from FDA Commissioner Scott Gottlieb, M.D., on how new regulatory authorities will assist the agency in more forcefully addressing opioid crisis; included as part of the newly enacted Substance Use-Disorder Prevention that Promotes Opioid Recovery and Treatment (SUPPORT) for Patients and Communities Act - FDA Press Releases

The SUPPORT Act grants FDA additional authorities to meaningfully advance efforts to combat the crisis of opioid addiction plaguing our nation.

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Sirob Imports, Inc. Issues Recall Due to Elevated Lead in Spices - FDA Safety Alerts & Drug Recalls

Sirob Imports, Inc of Lindenhurst, NY is recalling, Corrado, Orlando Imports, Nouri’s Syrian Bakery, Mediterranean Specialty Foods Brand and Butera Fruit Market Curry Powder because it contains elevated levels of lead.

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FDA approves new drug to treat influenza - FDA Press Releases

FDA approved Xofluza (baloxavir marboxil) to treat acute uncomplicated flu in patients 12 years old and older who have been symptomatic for less than 48 hours.

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G & C Raw, LLC is Expanding Recall to Include All Product Lots Manufactured from February 27, 2018 Through July 20, 2018, Because of Possible Listeria Monocytogenes Health Risk - FDA Safety Alerts & Drug Recalls

G & C Raw, of Versailles, OH is recalling all products lots manufactured from February 27, 2018 through July 20, 2018, as a precaution because they have the potential to be contaminated with Listeria monocytogenes

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Ala-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine Streptomyces sp. ICN19 - Journal of Antibiotics

Ala-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine Streptomyces sp. ICN19

Ala-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine <i>Streptomyces</i> sp. ICN19, Published online: 24 October 2018; doi:10.1038/s41429-018-0115-2

Ala-geninthiocin, a new broad spectrum thiopeptide antibiotic, produced by a marine Streptomyces sp. ICN19

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Federal judge enters consent decree against Tennessee over-the-counter drug manufacturer - FDA Press Releases

A federal court orders a Tennessee-based company to stop selling over-the-counter (OTC) drug products

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FDA launches global operation to crack down on websites selling illegal, potentially dangerous drugs; including opioids - FDA Press Releases

FDA warns website networks as part of global crack down for selling illegal pharmaceuticals

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New Seasons Market Issues Allergy Alert on Undeclared Soy in Hot & Sour Broth - FDA Safety Alerts & Drug Recalls

New Seasons Market is recalling 193 jars of New Seasons Market Hot & Sour Broth because it contains undeclared soy. People who have an allergy or severe sensitivity to soy run the risk of serious or life-threatening allergic reaction if they consume these products.

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Statement from FDA Commissioner Scott Gottlieb, M.D., on agency’s efforts to advance new ways to increase the availability of naloxone as one means for reducing opioid overdose deaths - FDA Press Releases

Statement from FDA Commissioner Scott Gottlieb, M.D., on agency’s efforts to advance new ways to increase the availability of naloxone as one means for reducing opioid overdose deaths

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MS network-based screening for new antibiotics discovery - Journal of Antibiotics

MS network-based screening for new antibiotics discovery

MS network-based screening for new antibiotics discovery, Published online: 23 October 2018; doi:10.1038/s41429-018-0109-0

MS network-based screening for new antibiotics discovery

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Promise Pharmacy Issues Voluntary Nationwide Recall of Prednisolone and Gatifloxacin Ophthalmic Solution 1%/0.5% Sterile Due to Small Particulate Floating in the Solution - FDA Safety Alerts & Drug Recalls

Promise Pharmacy is voluntarily recalling one lot of Prednisolone and Gatifloxacin Ophthalmic Solution 1%/0.5% sterile, 3ml vials, to the patient consumer level. The product has been found to have unidentified small particulate floating in the solution.

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Statement from FDA Commissioner Scott Gottlieb, M.D., on agency’s ongoing commitment to improving efficiency, transparency of tobacco product application review process as part of FDA’s comprehensive framework to reduce tobacco-related disease and death - FDA Press Releases

Statement from FDA Commissioner Scott Gottlieb, M.D., on agency’s ongoing commitment to improving efficiency, transparency of tobacco product application review process as part of FDA’s comprehensive framework to reduce tobacco-related disease and death.

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Working Cow Homemade, Inc. Expands Recall of Ice Cream Products Because of Possible Health Risk - FDA Safety Alerts & Drug Recalls

Working Cow Homemade, Inc. of St. Petersburg, FL is expanding its voluntary recall to include all ice cream manufactured from August 29, 2017 – October 11, 2018, because it has the potential to be contaminated with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems. Although healthy individuals may suffer only short-term symptoms such as high fever, severe headache, stiffness, nausea, abdominal pain and diarrhea, Listeria infection can cause miscarriages and stillbirths among pregnant women. This is an expansion of an earlier recall.

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Cedar’s Mediterranean Foods Issues Allergy Alert on Undeclared Soy in Cedar’s Chickpea Salad 8 oz. - FDA Safety Alerts & Drug Recalls

Cedar’s Mediterranean Foods, of Ward Hill, MA is voluntarily recalling Cedar’s Chickpea Salad 8 oz. because it may contain undeclared edamame (soy). People who have an allergy or severe sensitivity to soy run the risk of serious or life-threatening allergic reaction if they consume these products.

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Statement by FDA Commissioner Scott Gottlieb, M.D., on FDA’s new steps to help produce farmers, processors more effectively comply with food safety requirements - FDA Press Releases

Statement from FDA Commissioner Scott Gottlieb, M.D., on FDA’s new steps to help produce farmers, fresh-cut produce processors more effectively comply with food safety requirements

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Hy-Vee Voluntarily Recalls Several Meat and Potato Products - FDA Safety Alerts & Drug Recalls

Hy-Vee, Inc., based in West Des Moines, Iowa, is voluntarily recalling six of its meat and potato products across its eight-state region due to possible contamination with Salmonella and Listeria monocytogenes. The potential for contamination was discovered after Hy-Vee’s supplier, McCain Foods, announced it was recalling its caramelized mushrooms and fire-roasted tomatoes, which are ingredients that are used in six Hy-Vee products. To date, no illnesses have been reported in connection with these products.

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Trump Administration Launches “Winning on Reducing Food Waste” Initiative - FDA Press Releases

The U.S. Department of Agriculture (USDA), the U.S. Environmental Protection Agency (EPA), and the U.S. Food and Drug Administration (FDA) today announced the signing of a joint agency formal agreement under the "Winning on Reducing Food Waste" initiative.

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Stewart’s Shops Issues Allergy Alert on Undeclared Milk in Cranberry Apple Refresher - FDA Safety Alerts & Drug Recalls

Saratoga Springs, NY - Stewart’s Shops Corp. is recalling units of Stewart’s Shops brand Cranberry Apple Refresher 16 fluid oz. because the product may contain undeclared milk. People who have an allergy to milk run the risk of serious or life-threatening allergic reaction if they consume this product. Approximately 2,300 units of affected product were distributed in upstate New York and Southern Vermont.

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P. East Trading Corp. Issues Alert on Undeclared Sulfites In Fruits Du Sud Golden Seedless Raisins - FDA Safety Alerts & Drug Recalls

P. EAST TRADING CORP. of Bronx, NY is recalling Fruits Du Sud Golden Seedless Raisins (Lot No. FDS T499/18) 30 lbs Box, because they contain undeclared SULFITES. People who have a severe sensitivity to sulfites run the risk of serious or life-threatening reactions if they consume these products.

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SLR Food Distribution Inc. Issues Alert on Undeclared Sulfites in Sugar Melon Candy - FDA Safety Alerts & Drug Recalls

SLR Food Distribution Inc. of New Hyde Park, NY is recalling its 7.04oz package of SUGAR MELON CANDY / WAX GOURD because it contains undeclared sulfites. Consumers who have severe sensitivity to sulfites run the risk of serious or life-threatening allergic reactions if they consume this product.

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New Nan Fong Hong Trading Inc. Issues Allergy Alert on Undeclared Sulfites in Source Day Natural Treasures Dried Liquorice Slice - FDA Safety Alerts & Drug Recalls

New Nan Fong Hong Trading Inc. is recalling its 16 oz (454g) packages of Source Day Natural Treasures Dried Liquorice Slice because they contain undeclared sulfites. Consumers who are allergic to sulfite allergens run the risk of serious or life-threatening allergic reactions if they consume this product.

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Faribault Foods, Inc. Announces Voluntary Recall of a Limited Quantity of S&W Brand White Beans Due to the Presence of Undeclared (Sulfites) - FDA Safety Alerts & Drug Recalls

Faribault Foods, Inc. of Faribault, MN is recalling its 15 ounce S&W White Beans because it contains undeclared sulfites. People who have an allergy or severe sensitivity to sulfites run the risk of serious or life-threatening allergic reaction if they consume this product.

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Forthcoming Issues - Geriatrics

Surgery and the Geriatric Patient

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Contents - Geriatrics

John E. Morley

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Contributors - Geriatrics

JOHN E. MORLEY, MB, BCh

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Copyright - Geriatrics

ELSEVIER

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Alzheimer Disease and Other Dementias - Geriatrics

CLINICS IN GERIATRIC MEDICINE

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Patient-Centered Care and Cognitive Dysfunction - Geriatrics

Cognitive dysfunction is one of the most common conditions to plague older persons.1 Approximately 20% of persons over 70 years of age have dementia and another 20% have mild cognitive impairment. Physicians are not very good at recognizing older persons with cognitive impairment. This results in the patients following medical instructions poorly (eg, taking medicines improperly, inability to use inhalers or to measure glucose levels accurately). In addition, cognitively impaired older persons tend to continue to drive when it is dangerous and often continue to manage their own financial affairs.

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Screening for Cognitive Impairment in Geriatrics - Geriatrics

There are many instruments for screening cognitive impairment. The common tools for screening cognitive impairment are categorized into 4 groups (very brief, brief, self-administered, and test batteries) in geriatrics. There are some tests used for specific tests of 6 cognitive domains (learning and memory, language, executive function, complex attention, and social cognition) by following the DSM-V criteria. Different settings, stages, conditions, and specific people need some specific tools for screening cognitive impairment. It must be noted that there is some harm in screening for cognitive impairment in geriatrics.

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Clackamas Bakery Recalls Fred Meyer Bakery Angel Food Cake Bar Due to Undeclared Allergens - FDA Safety Alerts & Drug Recalls

Clackamas Bakery has recalled Fred Meyer Bakery Angel Food Cake Bar (12 oz.) sold in its retail stores because the product may contain milk and soy not listed on the label. Clackamas Bakery initiated the recall when it was discovered that the Fred Meyer Bakery Angel Food Cake Bar label had been incorrectly applied to packages of cornbread.

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FDA and DHS increase coordination of responses to medical device cybersecurity threats under new partnership; a part of the two agency’s broader effort to protect patient safety - FDA Press Releases

FDA and DHS announce partnership to address medical device cybersecurity threats

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Cyathane diterpenoids and drimane sesquiterpenoids with neurotrophic activity from cultures of the fungus Cyathus africanus - Journal of Antibiotics

Cyathane diterpenoids and drimane sesquiterpenoids with neurotrophic activity from cultures of the fungus Cyathus africanus

Cyathane diterpenoids and drimane sesquiterpenoids with neurotrophic activity from cultures of the fungus <i>Cyathus africanus</i>, Published online: 16 October 2018; doi:10.1038/s41429-018-0106-3

Cyathane diterpenoids and drimane sesquiterpenoids with neurotrophic activity from cultures of the fungus Cyathus africanus

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Feel Good Foods Inc Issues Allergy Alert on Undeclared Egg Product In “Vegetable Fried Rice” - FDA Safety Alerts & Drug Recalls

Feel Good Foods Inc. of Brooklyn, NY is recalling six lots of “Vegetable Fried Rice” frozen meals, UPC 00899039002129 because they may contain undeclared egg. People who have allergies to egg run the risk of serious or life-threatening allergic reaction if they consume these products.

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Fat Burners Zone Issues Voluntary Nationwide Recall of Zero Xtreme Due to Presence of Undeclared Sibutramine - FDA Safety Alerts & Drug Recalls

Fat Burners Zone is voluntarily recalling 1 lot of Zero Xtreme, capsules to the consumer level. FDA analysis has found Zero Xtreme to be tainted with sibutramine. Sibutramine is an appetite suppressant that was withdrawn from the U.S. market due to safety concerns. The presence of Sibutramine in Zero Xtreme renders it an unapproved drug for which safety and efficacy has not been established and, therefore, subject to recall.

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Apollo Food International Inc Issues Allergy Alert on Undeclared Eggs In “Mini Roll” - FDA Safety Alerts & Drug Recalls

Apollo Food International Inc. of Long Island City, NY, is recalling its 2.469 ounce packages of “Mini Roll” food treats because they may contain undeclared eggs. Consumers who are allergic to eggs may run the risk of serious or life-threatening allergic reactions if they consume this product.

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Statement by FDA Commissioner Scott Gottlieb, M.D., on FDA’s new steps to modernize drug development, improve efficiency and promote innovation of targeted therapies - FDA Press Releases

FDA issues two guidance documents to provide drug developers greater clarity and direction as they pursue the next generation of therapies and treatments for patients.

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FDA advances investigation into whether more than 40 e-cigarette products are being illegally marketed and outside agency's compliance policy - FDA Press Releases

FDA advances investigation into whether more than 40 e-cigarette products are being illegally marketed and outside agency's compliance policy

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Voluntary Recall of Limited Amounts of Nuts & Vanilla Protein Plant Shake - FDA Safety Alerts & Drug Recalls

Forager Project is recalling three dates of Nuts and Vanilla – Organic Plant Protein Shake because the product contains almond flour which is not declared on the label.

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Synthesis and evaluation of biological activity of benzoxaborole derivatives of azithromycin - Journal of Antibiotics

Synthesis and evaluation of biological activity of benzoxaborole derivatives of azithromycin

Synthesis and evaluation of biological activity of benzoxaborole derivatives of azithromycin, Published online: 12 October 2018; doi:10.1038/s41429-018-0107-2

Synthesis and evaluation of biological activity of benzoxaborole derivatives of azithromycin

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Suicide in the Elderly - Geriatrics

Suicide in the elderly is a growing problem. The elderly population is increasing, and elderly patients have multiple issues that place them at higher risk of suicidality. These issues include physical illnesses, mental illness, loss of functional status, isolation, and family, financial, and social factors. Access to firearms is another significant risk factor, because elderly patients are more likely to use firearms in suicide attempts; interventions to reduce firearms mortality may save lives. Tackling the difficult problem of suicide in the elderly may require a multidisciplinary, community-based series of interventions.

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Vascular Surgery and Geriatric Patients - Geriatrics

As the population ages, surgical decision-making in vascular surgery has become more complex. Older patients may not have been offered vascular surgical intervention in the past because of prohibitive physiologic demands and poor health. Patients now have more aggressive management of vascular risk factors with medications, such as statin therapy, and less invasive endovascular or hybrid treatment options. Outcomes in elderly patients may not be comparable with younger patients for entities such as aortic aneurysm repair, carotid endarterectomy, or lower extremity revascularization. Despite this, desirable outcomes can be successfully achieved and should be offered to carefully selected elderly individuals.

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Orthopedic Surgery and the Geriatric Patient - Geriatrics

As more patients live longer, it is probable that an increasing number of geriatric patients will require surgery. An organized, systematic, coordinated, multidisciplinary approach to the perioperative management of these patients will result in fewer complications, improved outcomes, and reduced cost of care. Details are herein provided on the preoperative diagnostic evaluation and assessment as well as perioperative care provided to optimize outcomes. The diagnosis, workup, and treatment of osteoporosis and fragility fractures are presented. The article concludes with a review of the care of the geriatric orthopedic patient in the posthospital time period.

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Changing Epidemiology of the American Population - Geriatrics

The changing epidemiology of the geriatric population in the United States has diverse social, medical, and financial implications that will continue to expand over the next few decades. According to the US Census Bureau, 20% of the US population will be 65 years or older by 2030 and more than 50% will eventually belong to a minority group. These changes are expected to be accompanied by several effects on the geriatric population’s demographics, injury characteristics, surgical interventions, and the cost of caring for the geriatric population, which will ultimately broaden the financial burden.

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FDA approves new DNA-based test to determine blood compatibility - FDA Press Releases

FDA approves new DNA-based test to determine blood compatibility.Test is first of this type approved to report genotypes as final results

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Isolation and structure determination of a new cytotoxic peptide, curacozole, from Streptomyces curacoi based on genome mining - Journal of Antibiotics

Isolation and structure determination of a new cytotoxic peptide, curacozole, from Streptomyces curacoi based on genome mining

Isolation and structure determination of a new cytotoxic peptide, curacozole, from <i>Streptomyces curacoi</i> based on genome mining, Published online: 11 October 2018; doi:10.1038/s41429-018-0105-4

Isolation and structure determination of a new cytotoxic peptide, curacozole, from Streptomyces curacoi based on genome mining

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Liveyon, LLC Issues a Voluntary Nationwide Recall of the Regen Series ® Product, Manufactured by Genetech, Inc. - FDA Safety Alerts & Drug Recalls

Liveyon, LLC (“Liveyon”) is a distributor of stem cell products manufactured by Genetech, Inc. (“Genetech”), a laboratory located in San Diego, CA. Liveyon marketed and distributed these products under the trade name ReGen Series®. Liveyon has voluntarily recalled all ReGen Series® products due to reported possible adverse reactions.

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Voluntary Recall Issued for Sweet Me Creamery Brookie Dough Ice Cream that may Contain an Undeclared Peanut Allergen - FDA Safety Alerts & Drug Recalls

Kemps of St. Paul, Minn., is voluntarily recalling Sweet Me Creamery Brookie Dough ice cream, individual pints and pint four-packs, because it may contain an undeclared peanut allergen. Individuals who have an allergy or severe sensitivity to peanuts run the risk of a serious or life-threatening allergic reaction if they consume these products.

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Sprayology Issues Voluntary Nationwide Recall of Homeopathic Aqueous-Based Medicines Due to Microbial Contamination - FDA Safety Alerts & Drug Recalls

Eight and Company LLC, d/b/a Sprayology is voluntarily recalling all lots within expiry from 10/18-7/22 of its aqueous-based homeopathic product line for human use. All products manufactured by the contract manufacturer, King Bio, have been recalled due to possible microbial contamination.

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Bazzini LLC Recalls Certain Pistachio Products Because of Possible Health Risk - FDA Safety Alerts & Drug Recalls

BazziniI LLC of Allentown, PA out of an abundance of caution, is recalling 4,000 pounds of Roasted and Salted Colossal Natural, Super Colossal Natural and Rams Head Natural in Shell Pistachios received from one of its suppliers because it has the potential to be contaminated with Salmonella. NO OTHER BAZZINI PISTACHIOS OR BAZZINI PRODUCTS ARE IMPACTED OR PART OF THIS RECALL. The recall is being initiated voluntarily and no illnesses have been reported to date.

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Helvamide, a new inhibitor of sterol O-acyltransferase produced by the fungus Aspergillus nidulans BF-0142 - Journal of Antibiotics

Helvamide, a new inhibitor of sterol O-acyltransferase produced by the fungus Aspergillus nidulans BF-0142

Helvamide, a new inhibitor of sterol <i>O</i>-acyltransferase produced by the fungus <i>Aspergillus nidulans</i> BF-0142, Published online: 10 October 2018; doi:10.1038/s41429-018-0101-8

Helvamide, a new inhibitor of sterol O-acyltransferase produced by the fungus Aspergillus nidulans BF-0142

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La FDA aprueba el uso ampliado de Gardasil 9 para incluir a personas de 27 a 45 años de edad - FDA Press Releases

La FDA aprueba el uso ampliado de Gardasil 9 para incluir a personas de 27 a 45 años de edad

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Ukrop’s Homestyle Foods, LLC Announces Recalls Because of Possible Health Risk - FDA Safety Alerts & Drug Recalls

Johnston County Hams’ country ham was recalled due to its potential for contamination with Listeria monocytogenes; therefore, Ukrop’s made the decision that any products that contained country ham or came into contact with equipment used to process the country ham are being recalled due to the potential to be contaminated with Listeria monocytogenes.

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Statement from FDA Commissioner Scott Gottlieb, M.D., on new efforts to advance the development of generic copies of complex drugs to improve patient access to medicines - FDA Press Releases

FDA issued a new series of guidance documents that will advance the development of generic transdermal and topical delivery systems

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Falls in the Geriatric Patient - Geriatrics

Falls in older adults are multifaceted, and are caused by biologic, behavioral, environmental, and socioeconomic risk factors. An estimated 25% of older adults fall each year. With 10,000 people turning 65 each day, it is essential that those at highest risk receive intervention to decrease the risk and rate of falls. In addition, those older adults at lower risk still need to understand the risk of falls and be educated about maintaining healthy lifestyles. Fall risk assessment and referral to individualized or group-based programming can reduce fall risks and falls.

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Utilization of Geriatric Consultation and Team-Based Care - Geriatrics

Geriatric surgical patients experience higher mortality and morbidity rates than their younger counterparts. Three models of geriatric surgical care are described, with a focus on people, plans, and evaluation. These models include geriatric consultation services, geriatric wards, and geriatric multidisciplinary teams. The optimal care plan should be definitive, aggressive, sustainable, safe, and effective, with consideration for patient treatment preferences and wishes.

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Ladyfingers Gourmet to Go Voluntarily Recalls Signature Shaved Country Ham Rolls Due to Possible Health Risk - FDA Safety Alerts & Drug Recalls

Ladyfingers Caterers is voluntarily recalling its Signature Shaved Country Ham Rolls as a result of the Johnston County Hams recall. The rolls were made with ham produced by Johnston County Hams, which recently initiated a recall of its ham products due to possible contamination with Listeria monocytogenes. Listeria monocytogenes can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems. Although healthy individuals may suffer only short-term symptoms such as high fever, severe headache, stiffness, nausea, abdominal pain and diarrhea, Listeria infection can cause miscarriages and stillbirths among pregnant women.

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Driving in the Geriatric Population - Geriatrics

Driving helps older adults stay mobile and independent. The risk of being injured or killed in a motor vehicle crash increases with age. This trend has been attributed more to an increased susceptibility to injury and medical complications among older drivers rather than an increased risk of crash involvement. Older adults tend to take steps to stay safe on the road. They tend to have a high incidence of seat belt use and a lower incidence of impaired driving. Furthermore, older drivers self-select safer driving conditions by avoiding night, bad weather, and high-speed roads compared with younger drivers.

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Elder Abuse - Geriatrics

Elder abuse is generally defined as the maltreatment of individuals over the age of 60, although no precise definition exists in the literature. Types of abuse include, but are not limited to, psychological/emotional, physical, sexual abuse, and financial exploitation. Certain risk factors exist leaving an individual more susceptible to abuse, and many obstacles exist preventing the elimination of abuse. There are also identifiable risk factors that increase the likelihood of perpetration of abuse. This systematic review provides an overview of the scope of the problem, types of abuse, risk factors, characteristics of abusers, and key aspects of elder abuse prevention.

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FDA approves expanded use of Gardasil 9 to include individuals 27 through 45 years old - FDA Press Releases

FDA approves expanded use of Gardasil 9 to include individuals 27 through 45 years old

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Consumer Alert: Sprout Creek Farm “Margie” Cheese Batch Recalled - FDA Safety Alerts & Drug Recalls

Today the New York State Department of Agriculture and Markets alerted consumers to a pasteurization problem with one of Sprout Creek Farm's pasteurized cow's milk cheeses, "Margie," made on 8/28/2018. Sprout Creek Farm is located in Poughkeepsie, NY. The reason for the recall is the air temperature at the start and end of the pasteurization process is required to be above 150deg F per the Grade "A" Pasteurized Milk Ordinance; the batch in question did not meet that standard. The recall pertains only to "Margie" cheese with a Made Date of 8/28/2018 and Best By date of 11/12/2018. To date, no illnesses have been reported to the Department in connection with this product.

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Callie's Charleston Biscuits Issues Voluntary Product Recall for Country Ham Biscuits and Cocktail Ham Biscuits Produced Using Johnston County Hams - FDA Safety Alerts & Drug Recalls

Johnston County Hams, Inc. issued a voluntary recall on October 3, 2018 for approximately 89,096 pounds of ready-to-eat ham products due to possible contamination with Listeria monocytogenes. In response, Callie's Charleston Biscuits, LLC is issuing a voluntary product recall for two products that may contain the potentially affected Johnston County Hams.

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Working Cow Homemade, Inc. Recalls Product Because of Possible Health Risk - FDA Safety Alerts & Drug Recalls

Working Cow Homemade Ice Cream, Inc. of St. Petersburg, FL is conducting a voluntary recall of No Sugar Added Vanilla and No Sugar Added Chocolate ice cream manufactured in three-gallon tubs during the month of May 2018. The recall is being conducted due to a potential contamination with Listeria monocytogenes, an organism which can cause serious and sometimes fatal infections in young children, frail or elderly people, and others with weakened immune systems. Although healthy individuals may suffer only short-term symptoms such as high fever, severe headache, stiffness, nausea, abdominal pain and diarrhea, Listeria monocytogenes infection can cause miscarriages and stillbirths among pregnant women.

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FDA allows marketing of first self-fitting hearing aid controlled by the user - FDA Press Releases

FDA allows marketing of a new device, the Bose Hearing Aid, intended to amplify sounds for individuals 18 years or older with perceived mild to moderate hearing impairment (hearing loss). This is the first hearing aid authorized for marketing by the FDA that enables the user to fit, program and control the hearing aid on his or her own, without assistance from a health care provider.

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Silver Star Brands, Inc. Issues Voluntary Nationwide Recall of Human and Animal Drug Products Due to Microbial Contamination - FDA Safety Alerts & Drug Recalls

Silver Star Brands, Inc., is initiating a voluntary recall of six products for humans (including four Native Remedies® and two Healthful Naturals™) and two PetAlive® products for pets for a total of eight products with lot numbers, see table below, to the consumer level. The products have been tested and found to contain microbial contamination.

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Transitions of Care in Geriatric Medicine - Geriatrics

Elderly patients are at increased risk for morbidity and mortality after injury or surgery in both the inpatient and postdischarge settings. The importance of discharge destination after the index hospitalization is increasingly recognized as a determinant of long-term survival, with discharge to a post–acute care facility portending a worse prognosis. Efforts to minimize discharge to post–acute care facilities should include early discharge planning. Communication among a multidisciplinary care team sets the groundwork for effective discharge planning and transitions of care. The elderly face several systematic, psychosocial, functional, and financial barriers that pose significant challenges to successful transitions of care.

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Frailty and Prognostication in Geriatric Surgery and Trauma - Geriatrics

Frailty is a predominant predictor of poor outcomes in older populations. This article presents a review of the concept of frailty and its role for prognostication among geriatric trauma and surgery patients. We discuss models of frailty defined in the scientific literature, emphasizing that frailty is a process of biologic aging. We emphasize the importance of screening, assessment, and inclusion of frailty indices for the development and use of prognostication instruments/tools in the population of interest. Finally, we discuss best practices for the delivery of prognostic information in acute care settings and specific recommendations for trauma and surgical care settings.

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Statement from FDA Commissioner Scott Gottlieb, M.D., on new agency actions to further deter ‘gaming’ of the generic drug approval process by the use of citizen petitions - FDA Press Releases

FDA issues revised guidance to allow for a more efficient approach to 505(q) petitions and focus more resources on scientific reviews.

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Statement from FDA Commissioner Scott Gottlieb, M.D. on FDA’s efforts to strengthen the agency’s medical device cybersecurity program as part of its mission to protect patients - FDA Press Releases

FDA’s efforts to strengthen the agency’s medical device cybersecurity program as part of its mission to protect patients

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