Objectives
To evaluate the effect of cognitive training on cognition and health-related quality of life (HRQoL) in community-dwelling persons with dementia.
Design
Single-blind randomized controlled trial with 3- and 9-month follow-up.
Setting
Adult day care centers in Helsinki, Finland.
Participants
Older individuals with mild to moderate dementia living at home and attending adult day care twice a week (N = 147; mean age 83, 72% female, 63% at mild stage of dementia).
Intervention
A systematic 12-week training program focused on subskills of executive function: attention, working memory, cognitive flexibility, and planning. The intervention group (n = 76) underwent cognitive training twice a week for 45 minutes, and the control group (n = 71) attended day care as usual.
Measurements
Primary outcomes were the Alzheimer's Disease Assessment Scale—Cognitive subscale (ADAS-Cog) for global cognition and the 15-dimensional instrument (15D) for HRQoL. The outcomes were measured at baseline and 3 and 9 months.
Results
Both groups deteriorated in global cognition and HRQoL during follow-up, and there were no differences between the two groups in change on the ADAS-Cog (P = .43) or 15D (P = .61) over time (adjusted for age and sex). At 3 months, changes were 0.8 (95% confidence interval (CI) = −0.2–1.8) for the intervention group and 1.7 (95% CI = 0.6–2.7) for the control group on the ADAS-Cog and −0.040 (95% CI = −0.058 to −0.021) for the intervention group and −0.037 (95% CI = −0.056 to −0.018) for the control group on the 15D.
Conclusion
Systematic cognitive training had no effect on global cognition or HRQoL in community-living persons with mild to moderate dementia.
from Journal of the American Geriatrics Society http://ift.tt/2ETZ4Gq
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