OBJECTIVES
Although elevated lipid levels predict increased risk of coronary heart disease and death in middle‐aged women and men, evidence is mixed if lipid levels measured in later life predict survival to very old ages. We examined lipid levels and survival to age 90 with or without intact mobility in a large cohort of older women.
DESIGN
Prospective cohort.
SETTING
Laboratory collection at a Women's Health Initiative (WHI) center and longitudinal follow‐up via mail.
PARTICIPANTS
Women aged 68 to 81 years at baseline.
MEASUREMENTS
Serum high‐density lipoprotein (HDL) and low‐density lipoprotein (LDL) cholesterol were collected at baseline. Participant survival status and self‐reported mobility was compared across lipid levels.
RESULTS
HDL and LDL levels were not associated with survival to age 90 after adjustment for cardiovascular risk factors (HDL: quartile (Q) 2: odds ratio [OR] = 1.14 [95% confidence interval [CI] = .94‐1.38]; Q3 OR = 1.08 [95% CI = .88‐1.33]; Q4 OR = 1.09 [95% CI = .88‐1.35]; LDL: Q2 OR = 1.07 [95% CI = .88‐1.31]; Q3 OR = 1.27 [95% CI = 1.04‐1.55]; Q4 OR = 1.07 [95% CI = .88‐1.31]). Similarly, no associations were observed between HDL and LDL levels and survival to age 90 with mobility disability. High HDL was not associated with survival to age 90 with intact mobility after adjustment for other cardiovascular risk factors. Compared with the lowest LDL quartile, the three upper LDL quartiles were associated with greater odds of survival to age 90 with intact mobility (LDL: Q2 OR = 1.31 [95% CI = .99‐1.74]; Q3 OR = 1.43 [95% CI = 1.07‐1.92]; Q4 OR = 1.35 [95% CI = 1.01‐1.80]; P = .05).
CONCLUSION
Neither higher HDL nor lower LDL levels predicted survival to age 90, but higher LDL predicted healthy survival. These findings suggest the need for reevaluation of healthy LDL levels in older women.
from Wiley: Journal of the American Geriatrics Society: Table of Contents https://ift.tt/30jxoXl
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