Objectives
To determine whether improvements in aerobic capacity (VO2peak) and strength after progressive resistance training (PRT) mediate improvements in cognitive function.
Design
Randomized, double-blind, double-sham, controlled trial.
Setting
University research facility.
Participants
Community-dwelling older adults (aged ≥55) with mild cognitive impairment (MCI) (N = 100).
Intervention
PRT and cognitive training (CT), 2 to 3 days per week for 6 months.
Measurements
Alzheimer's Disease Assessment Scale–cognitive subscale (ADAS-Cog); global, executive, and memory domains; peak strength (1 repetition maximum); and VO2peak.
Results
PRT increased upper (standardized mean difference (SMD) = 0.69, 95% confidence interval = 0.47, 0.91), lower (SMD = 0.94, 95% CI = 0.69–1.20) and whole-body (SMD = 0.84, 95% CI = 0.62–1.05) strength and percentage change in VO2peak (8.0%, 95% CI = 2.2–13.8) significantly more than sham exercise. Higher strength scores, but not greater VO2peak, were significantly associated with improvements in cognition (P < .05). Greater lower body strength significantly mediated the effect of PRT on ADAS-Cog improvements (indirect effect: β = −0.64, 95% CI = −1.38 to −0.004; direct effect: β = −0.37, 95% CI = −1.51–0.78) and global domain (indirect effect: β = 0.12, 95% CI = 0.02–0.22; direct effect: β = −0.003, 95% CI = −0.17–0.16) but not for executive domain (indirect effect: β = 0.11, 95% CI = −0.04–0.26; direct effect: β = 0.03, 95% CI = −0.17–0.23).
Conclusion
High-intensity PRT results in significant improvements in cognitive function, muscle strength, and aerobic capacity in older adults with MCI. Strength gains, but not aerobic capacity changes, mediate the cognitive benefits of PRT. Future investigations are warranted to determine the physiological mechanisms linking strength gains and cognitive benefits.
from Journal of the American Geriatrics Society http://ift.tt/2dQ8lod
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